Department of chemistry, Cadi Ayyad University, Faculty of Science Semlalia, Laboratory of reactivity of materials and process optimization, PB 2390, Marrakech, Morocco
The present work reports a comparative study of spontaneous crystalluria for non- and goitrous patients with the aim to determine its correlation with parathyroid gland activity and goiter etiology. The crystalluria was accessed based on optical polarized light microscopy (OPLM). Goiter presents high woman predominance with an average age of 35.6 years. The frequency of majority constituents in crystalluria is age dependent and amorphous complex carbonated phosphates (ACCP) and uric acid (UA) are the frequent chemical species. The observed hyperphosphaturia can be explained by the estrogen's activity on parathyroid cells proliferation. The presence of oxalo-calcic crystalluria confirms hyperparathyroidism as one of the hypercalciuric kidney stone etiology. Clinical goiter diagnostic and treatment could be followed and confirmed by a simple fluctuations follow-up of crystalluria composition according to phosphate and calcium species.
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