The link between inflation and economic growth has been the focus of recent decades among macroeconomists, policymakers and central banks in both developed and developing countries. In particular, the question of whether inflation is necessary or detrimental to economic growth has led to a theoretical debate and illustrated by empirical results. As far as we are concerned, we have analyzed the relationship between inflation and economic growth in Tunisia from 1980 to 2017. The VAR model (Vector auto Regressive) and the notion of Granger causality were used as a method. This study has shown that inflation has a negative effect on economic growth, hence the need to fight against this devastating plague. Targeting inflation seems a solution.