Negatively charged with rumors and painful memories from the start, the covid-19 vaccination campaign in the Democratic Republic of the Congo struggles to convince. The Congolese authorities are confronted with the distrust of the population with regard to the vaccine. If for some, it is the fear of being taken for guinea pigs that invades them, for others, covid-19 simply does not exist. And therefore, considering the vaccine as a cure-all for Covid-19 imperatively requires extricating it from social obscurantism, which plebiscites a number of prejudices and rumors at the origin of mistrust and reluctance. The communication strategies proposed as an alternative to a vast vaccination campaign have as an epistemological basis, the psychosociological approach to communication. This article presents the results of a survey conducted among a random sample of 428 Congolese across the country. It also lays the groundwork for an intervention model that highlights the psychosociological approach to communication as a driver of success in vaccination against Covid-19 in the DRC.