In December 2019 an outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 was first observed in Wuhan, China. The virus has spread rapidly throughout the world creating a pandemic scenario. The incidence of Covid-19 infection is influenced by several factors such as: lockdown, restriction measures, social distancing, use of face masks, environmental temperature and viral load, vaccinations. This study describes the evolution of the incidence of Covid-19 infection in Campania (Region of Southern Italy) from September 2020 to August 2021.