The use of medicinal plants such as Garcinia kola in the treatment of several diseases, including those considered incurable, is becoming increasingly common throughout the world in general and in Africa (Ivory Coast) in particular. This popularity can be explained especially by the therapeutic properties attributed to these plants. The objective of this study is to evaluate the safety of Garcinia kola seed extract prepared with koutoukou on the renal function of Wistar rats. The animal and plant material consisted of adult albino rats and Garcinia kola (Guttifferea) seeds, respectively. The preparation of plant extracts, phytochemical screening, Acute Oral Toxicity (AOT), determination of the LD50, blood tests, histological sections, and statistical analyses were performed using standard and certified methods. The yield of koutoukou extract (EKGK) is the highest (30.4 ± 0.61%). Phytochemical screening of EKGK reveals the presence of sterols and polyterpenes, polyphenols, flavonoids, catechin tannins, saponosides, and alkaloids with an LD50 greater than 2000 mg/kg of PC. Urea and creatinine did not increase significantly on day 14, confirming the absence of alterations in the renal parenchyma. In view of these results, it appears that EKGK belongs to the class of non-toxic substances and contains bioactive compounds that may confer therapeutic properties. Consumption of this cocktail showed no deleterious effects on renal function, a vital organ that plays a crucial role in body homeostasis.

In tropical environments, parasitosis is a public health problem. This study aims to describe the evolution of the prevalence of intestinal parasitosis diagnosed at the laboratory of the University Hospital of Abomey-Calavi/So-Ava in the Atlantic Department of southern Benin in West Africa from 2010 to 2020. Each stool sample was examined directly with physiological water and stained with Lugol’s stain. From 2010 to 2020, 2348 patients benefited from a parasitological examination of stools at the laboratory of the University Hospital of Abomey-Calavi/So-Ava. 181 samples were positive (8%). 53% of the patients with parasitic disease were female. Children aged 0 to 5 years represent 51% of the parasitized patients. 97.90% of the parasites identified during the parasitological examination of stools belong to the group of protozoa. Entamoeba histolytica is the most observed parasite species (64.64%), followed by Entamoeba coli (27.76%), Trichomonas intestinalis (3.30%), Giardia lamblia (2.20%), Ascaris lumbricoides (1.6%) and Trichuris trichiura (0.5%). An effective control of intestinal parasitosis in Benin will require the eradication of intestinal protozoosis.