The objectives of this study were to describe and analyze the modalities of prescription of psychotropic drugs in patients followed in ambulatory psychiatry. The study was cross-sectional, descriptive, and analytical on the prescription of psychotropic drugs in 205 patients followed at the outpatient clinic of the National Psychiatric Hospital of Thiaroye in Dakar, for a period of three months (from February 1 to April 30, 2019). The average age was 34.5 years, 64.9% of patients were without occupation and 15.6% had a history of hospitalization. The disorder had lasted between 1 - 10 years for 59.1% of patients. The most frequent diagnosis was schizophrenia (33.7%) followed by mood disorders (18.1%) and epilepsy (18.0%). The average number of medications per patient was 2.77 and monotherapy was exceptional (0.06% of patients). Antipsychotics were the most prescribed drugs (76.1%), followed by anxiolytics (31.7%), thymoregulators (27.3%), and antidepressants (23.4%). A synthetic antiparkinsonian was found in 51.2% of cases and delayed neuroleptics were prescribed in 13.7% of patients. Classic antipsychotics were prescribed in 50.4% of schizophrenic patients and second-generation antipsychotics in 33.3%. Second-generation antidepressants (serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors) were prescribed exclusively for depressive disorders and anxiety disorders, unlike tricyclics. One-third of bipolar patients (37.5%) received a combination of a thymoregulator and an antipsychotic. Contrary to antipsychotics, which are still dominated by the classics, we note a trend toward the prescription of new antidepressants. However, some prescriptions did not comply with international recommendations. It is important to set up national protocols, based on current scientific evidence but also on the socio-economic context of the country to optimize the quality of psychotropic drug prescriptions.