One of the acute complications of diabetes is diabetic ketoacidosis characterized by an increase in blood acidity and the formation of ketone bodies which are toxic to the body. It is from this understanding that we evaluated the impact of the consumption of a functional water-soluble salt formulated from sodium bicarbonate «Bicarbon-Plus» in alloxan induced diabetic rats. For this purpose, 4 batches of 8 rats of the Wistar strain were used. Anthropometric and biochemical parameters were accessed, as well as physiological tolerance. Bicarbon-Plus significantly reduced blood sugar and ketone levels in diabetic rats. The lost of lot of weight was observed in the diabetic rats that did not received Bicarbon-Plus. An increase in HDL-C levels was observed from the 14th to the 36th day in diabetic rats that consumed the Bicarbon-Plus. The diabetic rats having consumed 0.250 mL/100 g of b.w. Bicarbon-Plus, the ALT level decreased significantly, and the AST level was not significant compared to the diabetic control group. A decrease in creatine and urea levels was observed in diabetic rats that consumed Bicarbon-Plus. And diabetic rats that consumed Bicarbon-Plus have showed an extremely significant decrease in CRP levels, and an extremely significant increase in SOD levels. So Bicarbon-Plus is alkalizing, lowers ketonemia, hypoglycemic, increases HDL-C, anti-inflammatory, antioxidant, hepatoprotective, nephroprotective, and protects the mass of the pancreas. It is safe, and could be recommended for the treatment of diabetes.