The study investigated school facilities, financial factors and student’s interest on enrollment in technical and Vocational Education in Oyo state. Descriptive survey research design was adopted for the study. The population consists of all the students in some selected technical colleges in Oyo state. Three (3) schools were selected as sample to ensure even representation of the population. The sample population represents 60% of the technical colleges in Oyo state. The findings of the study revealed that there is a positive relationship between school facilities and TVE in the study area (r=. 319, p<0.05), There is a moderate positive relationship between financial factors and enrollment in TVE. (r=.152, p=0.05), there is a moderate positive relationship between student interest and enrollment in TVE. (r=.287, p=0.05). All the independent variables, facilities factor, financial factor and student interest contributes to enrollment in TVE there is a significant joint contribution of facilities, financial factor and student interest to enrollment in T V E. This study recommended that there should be provision of adequate facilities, funds for the effective operation of Technical and Vocational Education.