The Kan Lake plays a socio-economic role for the populations of Bouaké. However, due to increasing urbanization around it, the lake is becoming increasingly threatened. This study aims to examine the spatio-seasonal variations of the physico-chemical parameters of the lake. For this purpose, in-situ measurements and laboratory analyses were conducted using appropriate equipment. The results show that the Kan reservoir lake exhibits spatial homogeneity for certain parameters (temperature, pH, conductivity, salinity, dissolved oxygen, chlorine, alkalinity, hardness, iron, nitrite, nitrate, ammonium, orthophosphate, and transparency), but also significant variability for others (redox potential, depth). Seasonally, temperature, pH, redox potential, dissolved oxygen, salinity, chlorine, alkalinity, iron, nitrates, and nitrites vary significantly from one season to another. This situation illustrates the combined effect of tropical climatic conditions, water inputs, and human activities on the variation of physico-chemical parameters in the Kan reservoir lake. It also highlights the necessity to integrate seasonal variability into environmental management strategies to preserve water quality and aquatic biodiversity.