Sustainability and economic efficiency in corn production could increase by the integrated weed management to a tolerable level. A study was conducted at the Kasapa farm during the 2013-2014 crop year to assess growth, grain yield of two improved varieties of maize (UNILU and Bukidi-Bukidi) and production economics Starting from two modes of weeding (manual weeding hoe and chemical weeding) and 4 weed management alternatives: {Weeding Manual (TO), 3l / ha atrazine (T1), 3l / ha acetochlor (T2), 6l / ha atrazine and acetochlor mixture (T3)}. The results revealed that the two varieties were similar height perspective of seedlings and yield. Six species have been recorded, but only two species (Setaria pumila and Cyperus rotundus) were resistant to their presence in all plots. Compared to weed management practices, performance culture has evolved as follows: T2> T3> T1> T0.Cependant an acceptable economic return was obtained with 3l / ha acetochlor. To intensify maize production in the study area, the mixture of acetochlor and atrazine is Discourage while adoption of acetochlor requires an extension on these modes.