Toxoplasmosis is a zoonotic disease, recognized as a serious public health problem worldwide due to the ravaging HIV/AIDS pandemic. Who (2003) has reported that tuberculosis (TB) remains the leading cause of morbidity and mortality due to any one infectious agent worldwide. Few publications exist regarding Toxoplasma and tuberculosis co-infection. This study was carried out in Khartoum Sudan to assess T. gondii infection in Tuberclosis patientd. Modified latex agglutination test was used for screen of anti-toxoplasma antibodies. Antibodies to T. gondii were detected in 11 (17.2%) of the 64 individuals studied. Toxoplasmosis was higher in males (71.4%) than the females (28.6) and the infection observed in all age groups and was not associated with certain age group. Most of toxoplasmosis infected individuals (72.7%) were consuming meat frequently. Our finding showed that patients presenting active TB have significantly higher susceptibility to toxoplasmosis infection (25%) compared to active Tb free individuals (11%).