Menthone, is a monoterpene ketone, occurs in nature and widely present in high concentration in mentha species essential oils. Also, it has become the key to the synthesis of many heterocyclic compounds exhibiting various kinds of biological activity. The objective of the present work is to synthesize new menthone derivative compounds such as menthopyrazole (HPM) and 1-phenylmenthopyrazole (PMP) by condensation of hydroxymethylenementhone with hydrazine and phenylhydrazine, respectively. The structures of these compounds were characterized by FT-IR, 1H NMR and 13C NMR spectra.
New γ-lactam derivatives are synthesized with good yields on a mineral support in "dry" medium and under microwave irradiations in a domestic furnace. The structures of the various products are established using 1HNMR, 13CNMR and IR spectroscopy.
In this work, we report an efficient protocol containing the technique of microwave oven and its comparison with the conventional method (refluxing) for the synthesis of new derivatives pyridazinones namely 4-(p-alkylbenzylidene)pyridazin-3(2H)-ones. These are obtained by condensation of α-arylidene-γ-butyrolactones precursors and hydrazines in the presence of p-toluene sulfonic acid (PTSA). The structures of these new compounds were identified by spectral methods (1H, 13C NMR and IR).
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