The smock/fugu industry in the Upper east region of Ghana is one that offers employment opportunities to many both educated and non-educated alike. Though successive governments have made several pronouncements to help boost the industry, it is still bedevilled with many challenges. This paper therefore seeks to unveil some of the challenges that this industry face. This survey was conducted in the Bongo District, Bolgatanga Municipal and the Kassena-Nankana Municipal of the Upper East region of Ghana. The survey used questionnaires and interviews to gather data. In all, 90 manufacturers and 75 customers were questioned. The study found out that the smock weaving and sewing industry though employs many equipment challenges. Many manufacturers do not have enough equipment to cover all apprentices. Also when the smock is woven or sewn into smocks, the selling of the products become difficult due to non-availability of markets. The study therefore recommends that the District Assemblies should provide some assistance to the manufacturers’ in the form of markets and a festival to showcase these products.