The main purpose of this paper was to analyze recommendable technology package combining mineral and organic fertilizer that lead to agronomic and economic efficiency at farmer level. The test on six demonstration plots led to the conclusion that the treatment combining (15Kg N+15Kg P+10Kg K + 10Metric Tons of organic matter ) is efficient in Kalehe territory and Ruzizi plain because gives higher yields in terms of maize production with an average 5.3 MT of maize in Kalehe territory and 3.3MT in Ruzizi plain. Difference in yields for the two zones is mainly explained by the difference of potentials of soil productivity and production costs. Treatment combining (15Kg N+15KgP+10Kg K + 10MT Om) is the most productive in terms of additional yields that increases between 50 and 70% for Kalehe and between 15 and 36% in Ruzizi plain. On the economic aspect profitability of the same treatment (15Kg N+15KgP+10Kg K + 10 MT Om) is the highest in both zones Kalehe and Ruzizi plain. Average gross additional income attributable to the treatment combining the fertilizer package here above mentioned is 3,285$ per season and per hectar in Kalehe while the gross income attributable is 1,684$ in Ruzizi plain zones. Treatment (90KgN+30kgP+15kg K + 10MT om) is economically the most profitable in Ruzizi plain with 1,735 $/ha/harvest season. Estimated rate of financial return of treatment (15Kg N+15KgP+10Kg K + 10 MT Om) is 1.4 in Biriba, 2.8 in Kalehe-centre and 3.8 in Muhongoza. For treatment (90Kg N+30KgP+15KgK + 10MT of Om) the rate of financial return is 2 in Kiliba and 0.75 in Runingu for treatment (45KgN+15KgP+10Kg K + 10 MT of Om). It comes to the conclusion that technology package combining organic and mineral fertilizers increases significantly agronomic and economic efficiency. For farmers to increase yields and generate higher income these technology package are highly recommendable indeed.