Volume 10, Issue 2, February 2015, Pages 701–706
Muhammad Shoaib Akhtar1, Muhammad Imran Qayyum2, Nadeem Irshad3, Muhammad Yaseen4, Abid Hussain5, Hamza Altaf6, Saif-ur-Rehman7, and Nazir Suleman8
1 Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha-40100, Pakistan
2 Departement of pharmacy, faculty of medical and health sciences, The university of Poonch Rawalakot AJ&K, Pakistan
3 Hamdard Institute of Pharmaceutical sciences, Hamdard university Islamabad campus, Pakistan
4 Mohi-ud-Din institute of pharmaceutical sciences MirPur AJ&K, Pakistan
5 Departement of pharmacy, faculty of medical and health sciences, The university of Poonch Rawalakot AJ&K, Pakistan
6 Departement of pharmacy, faculty of medical and health sciences, The university of Poonch Rawalakot AJ&K, Pakistan
7 Departement of pharmacy, faculty of medical and health sciences, The university of Poonch Rawalakot AJ&K, Pakistan
8 Departement of pharmacy, faculty of medical and health sciences, The university of Poonch Rawalakot AJ&K, Pakistan
Original language: English
Copyright © 2015 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Liver dysfunction is a major health problem .Excessive drug therapy, free radicals, environmental pollutants, and alcoholic intoxicants are the main causes of liver disorders. The present investigation was designed to evaluate its in vivo hepatoprotective properties of Canscorra decussata (family Gentianaceae) whole plant methanolic extract against paracetamol toxicity in rabbits. Hepatoprotective activities of methanolic extracts of C. decussata were examined against paracetamole induced liver damage in rabbits using silymarin as control. Enzyme activities of Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), and Alkaline Phosphatase (ALP), bilirubin total and direct billiribin were analyzed. Oral administration of methanolic extract exhibited significant hepatoprotective activity.
Author Keywords: Canscorra decussata, Silymarin, Hepatoprotective, Intoxicants, Free redicals.
Muhammad Shoaib Akhtar1, Muhammad Imran Qayyum2, Nadeem Irshad3, Muhammad Yaseen4, Abid Hussain5, Hamza Altaf6, Saif-ur-Rehman7, and Nazir Suleman8
1 Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha-40100, Pakistan
2 Departement of pharmacy, faculty of medical and health sciences, The university of Poonch Rawalakot AJ&K, Pakistan
3 Hamdard Institute of Pharmaceutical sciences, Hamdard university Islamabad campus, Pakistan
4 Mohi-ud-Din institute of pharmaceutical sciences MirPur AJ&K, Pakistan
5 Departement of pharmacy, faculty of medical and health sciences, The university of Poonch Rawalakot AJ&K, Pakistan
6 Departement of pharmacy, faculty of medical and health sciences, The university of Poonch Rawalakot AJ&K, Pakistan
7 Departement of pharmacy, faculty of medical and health sciences, The university of Poonch Rawalakot AJ&K, Pakistan
8 Departement of pharmacy, faculty of medical and health sciences, The university of Poonch Rawalakot AJ&K, Pakistan
Original language: English
Copyright © 2015 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Liver dysfunction is a major health problem .Excessive drug therapy, free radicals, environmental pollutants, and alcoholic intoxicants are the main causes of liver disorders. The present investigation was designed to evaluate its in vivo hepatoprotective properties of Canscorra decussata (family Gentianaceae) whole plant methanolic extract against paracetamol toxicity in rabbits. Hepatoprotective activities of methanolic extracts of C. decussata were examined against paracetamole induced liver damage in rabbits using silymarin as control. Enzyme activities of Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), and Alkaline Phosphatase (ALP), bilirubin total and direct billiribin were analyzed. Oral administration of methanolic extract exhibited significant hepatoprotective activity.
Author Keywords: Canscorra decussata, Silymarin, Hepatoprotective, Intoxicants, Free redicals.
How to Cite this Article
Muhammad Shoaib Akhtar, Muhammad Imran Qayyum, Nadeem Irshad, Muhammad Yaseen, Abid Hussain, Hamza Altaf, Saif-ur-Rehman, and Nazir Suleman, “Hepatoprotective Properties of methanolic extract of Canscora decussata (Schult) against paracetamol induced liver toxicity in rabbits,” International Journal of Innovation and Applied Studies, vol. 10, no. 2, pp. 701–706, February 2015.
