Volume 14, Issue 2, January 2016, Pages 498–506
Wissal Mahir1, Lamiaa Rouas2, Mounir Ouzir3, Driss Ferhati4, Brahim Rhrab5, Zaitouna Alhamany6, and Nadia Cherradi7
1 Laboratory of Pathological Anatomy, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Morocco
2 Laboratory of Pathological Anatomy, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Morocco
3 Laboratory of Pathological Anatomy, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Morocco
4 Souissi Maternity Hospital 1, CHU of Rabat, Morocco
5 Souissi Maternity Hospital 1, CHU of Rabat, Morocco
6 Laboratory of Pathological Anatomy, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Morocco
7 Laboratory of Pathological Anatomy, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Morocco
Original language: English
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: The management of breast cancer is frequently based on hormone receptors [estrogen receptor (ER), progesterone receptor (PR)] and Human epidermal growth factor 2 (HER2). However, hormone receptors and HER2 status may change throughout tumor progression. The aim of this work is to correlate hormonal receptors with HER2 expression and also their correlation with other routinely used characteristics such as patient's age, tumor size, tumor grade, vascular space invasion and lymph node status in order to determine their prognostic value in infiltrating ductal carcinoma breast patients.
Methods: Seventy-eight paraffin-embedded infiltrating ductal carcinoma tissues from patients of mean age 50.33 (28 to 84) years were collected and studied using immunohistochemistry to evaluate RE, RP and HER2 status. In this retrospective study, samples were collected between January 2010 and December 2013 at the Children's Hospital of Rabat, Morocco.
Results: In our study, the prevalence of ER, PR expression and HER2 were 73,1%, 69,2% and 19,2% respectively. None of these biomarkers showed correlation with age, Tumor size and Lymph node. There was no association between HER2 expression and hormone receptors expression as well as their different phenotypes (ER/PR). On the other hand, we have found that HER2 was significantly associated with the presence of vascular space invasion (P=0.015), while the relationship between hormonal receptors expression and vascular space invasion was found to be not significant. Out of 78 cases, 50 patients expressed positively and simultaneously ER and PR. This relationship between ER and PR was significant (P<0.0001). In addition, the grade of tumor in our study was significantly correlated to the expression of ER (P=0.028), as well as HER2 and ER in Grade of tumor II (P=0.025).
Conclusions: Our results provide valuable prognostic information to guide the decision-making process for treatment of patient with infiltrating ductal carcinoma.
Author Keywords: Infiltrating ductal carcinoma, Estrogen receptors, Progesterone receptors, Human epidermal growth factor receptors, Immunohistochemistry.
Wissal Mahir1, Lamiaa Rouas2, Mounir Ouzir3, Driss Ferhati4, Brahim Rhrab5, Zaitouna Alhamany6, and Nadia Cherradi7
1 Laboratory of Pathological Anatomy, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Morocco
2 Laboratory of Pathological Anatomy, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Morocco
3 Laboratory of Pathological Anatomy, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Morocco
4 Souissi Maternity Hospital 1, CHU of Rabat, Morocco
5 Souissi Maternity Hospital 1, CHU of Rabat, Morocco
6 Laboratory of Pathological Anatomy, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Morocco
7 Laboratory of Pathological Anatomy, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Morocco
Original language: English
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: The management of breast cancer is frequently based on hormone receptors [estrogen receptor (ER), progesterone receptor (PR)] and Human epidermal growth factor 2 (HER2). However, hormone receptors and HER2 status may change throughout tumor progression. The aim of this work is to correlate hormonal receptors with HER2 expression and also their correlation with other routinely used characteristics such as patient's age, tumor size, tumor grade, vascular space invasion and lymph node status in order to determine their prognostic value in infiltrating ductal carcinoma breast patients.
Methods: Seventy-eight paraffin-embedded infiltrating ductal carcinoma tissues from patients of mean age 50.33 (28 to 84) years were collected and studied using immunohistochemistry to evaluate RE, RP and HER2 status. In this retrospective study, samples were collected between January 2010 and December 2013 at the Children's Hospital of Rabat, Morocco.
Results: In our study, the prevalence of ER, PR expression and HER2 were 73,1%, 69,2% and 19,2% respectively. None of these biomarkers showed correlation with age, Tumor size and Lymph node. There was no association between HER2 expression and hormone receptors expression as well as their different phenotypes (ER/PR). On the other hand, we have found that HER2 was significantly associated with the presence of vascular space invasion (P=0.015), while the relationship between hormonal receptors expression and vascular space invasion was found to be not significant. Out of 78 cases, 50 patients expressed positively and simultaneously ER and PR. This relationship between ER and PR was significant (P<0.0001). In addition, the grade of tumor in our study was significantly correlated to the expression of ER (P=0.028), as well as HER2 and ER in Grade of tumor II (P=0.025).
Conclusions: Our results provide valuable prognostic information to guide the decision-making process for treatment of patient with infiltrating ductal carcinoma.
Author Keywords: Infiltrating ductal carcinoma, Estrogen receptors, Progesterone receptors, Human epidermal growth factor receptors, Immunohistochemistry.
How to Cite this Article
Wissal Mahir, Lamiaa Rouas, Mounir Ouzir, Driss Ferhati, Brahim Rhrab, Zaitouna Alhamany, and Nadia Cherradi, “Correlation of ER, PR and HER2 with clinico-pathological parameters in Infiltrating Ductal Carcinoma of Breast in Morocco,” International Journal of Innovation and Applied Studies, vol. 14, no. 2, pp. 498–506, January 2016.
