[ La rupture prématurée des membranes : Intérêt de la CRP dans la prédiction de l’infection materno-fœtale ]
Volume 30, Issue 1, July 2020, Pages 96–102
Fatima E Hassouni1, Malika Mguil2, Fatima Zahra Belkouchi3, Nour Mekaoui4, and Sabah AMRANI5
1 Department of Gynecology-Obstetrics-Oncology and High-Risk Pregnancy, Souissi Maternity Hospital, Ibn Sina University Hospital Center, Rabat, Morocco
2 Department de sciences fondamentales, Faculté de médecine dentaire, Université Mohammed V, Rabat, Morocco
3 Service de gynécologie obstétrique cancérologie et grossesse à haut risque, Maternité Souissi, Université Mohamed V, Rabat, Morocco
4 Laboratoire de biostatistiques d’épidémiologie et de recherche clinique, Service des urgences médicales pédiatriques, Hôpital d’enfants, Université Mohammed V, Rabat, Morocco
5 Professeur en gynécologie obstétrique, Maternité SOUISSI, Rabat, Morocco
Original language: French
Copyright © 2020 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Introduction: Premature rupture of membranes represents a major infectious risk for the mother and the fetus; it constitutes a risk factor for chorioamniotitis, puerperal and neonatal sepsis. Reactive protein C is a biological marker widely used in the detection of maternal and fetal infections, in particular in the early diagnosis of chorioamniotitis. The aim of this study is to assess the role of CRP in the diagnosis of chorioamniotitis, and to correlate it with the prediction of neonatal infection and thus review the arguments concerning its usefulness. Materials and methods: This is a retrospective study of patients collected from the Kangaroo unit at the Souissi maternity hospital in Rabat between March 2018 and October 2018, including all parturients having delivered vaginally to an asymptomatic newborn in a premature rupture of membranes context. Clinical and biological monitoring, in particular with reactive protein C in mothers and newborns, was carried out. Results: 238 patients were admitted to the kangaroo service for delivery in premature rupture of the membranes context. In the positive maternal CRP group, 8 women had clinical chorioamiotitis, while no case of clinical chorioamniotitis was recorded in the negative CRP group. In the positive neonatal CRP group, all mothers had a positive CRP while in the neonatal negative CRP group 37.6% of the women had a positive CRP with a P <0.001. Conclusion: Our study suggests that a high rate of maternal CRP before childbirth is a good predictor of chorioamniotitis and neonatal infection.
Author Keywords: Maternal-fetal infection, chorioamniotitis, CRP, septicemia, premature rupture of the membranes.
Volume 30, Issue 1, July 2020, Pages 96–102
Fatima E Hassouni1, Malika Mguil2, Fatima Zahra Belkouchi3, Nour Mekaoui4, and Sabah AMRANI5
1 Department of Gynecology-Obstetrics-Oncology and High-Risk Pregnancy, Souissi Maternity Hospital, Ibn Sina University Hospital Center, Rabat, Morocco
2 Department de sciences fondamentales, Faculté de médecine dentaire, Université Mohammed V, Rabat, Morocco
3 Service de gynécologie obstétrique cancérologie et grossesse à haut risque, Maternité Souissi, Université Mohamed V, Rabat, Morocco
4 Laboratoire de biostatistiques d’épidémiologie et de recherche clinique, Service des urgences médicales pédiatriques, Hôpital d’enfants, Université Mohammed V, Rabat, Morocco
5 Professeur en gynécologie obstétrique, Maternité SOUISSI, Rabat, Morocco
Original language: French
Copyright © 2020 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction: Premature rupture of membranes represents a major infectious risk for the mother and the fetus; it constitutes a risk factor for chorioamniotitis, puerperal and neonatal sepsis. Reactive protein C is a biological marker widely used in the detection of maternal and fetal infections, in particular in the early diagnosis of chorioamniotitis. The aim of this study is to assess the role of CRP in the diagnosis of chorioamniotitis, and to correlate it with the prediction of neonatal infection and thus review the arguments concerning its usefulness. Materials and methods: This is a retrospective study of patients collected from the Kangaroo unit at the Souissi maternity hospital in Rabat between March 2018 and October 2018, including all parturients having delivered vaginally to an asymptomatic newborn in a premature rupture of membranes context. Clinical and biological monitoring, in particular with reactive protein C in mothers and newborns, was carried out. Results: 238 patients were admitted to the kangaroo service for delivery in premature rupture of the membranes context. In the positive maternal CRP group, 8 women had clinical chorioamiotitis, while no case of clinical chorioamniotitis was recorded in the negative CRP group. In the positive neonatal CRP group, all mothers had a positive CRP while in the neonatal negative CRP group 37.6% of the women had a positive CRP with a P <0.001. Conclusion: Our study suggests that a high rate of maternal CRP before childbirth is a good predictor of chorioamniotitis and neonatal infection.
Author Keywords: Maternal-fetal infection, chorioamniotitis, CRP, septicemia, premature rupture of the membranes.
Abstract: (french)
Introduction: La rupture prématurée des membranes représente un risque infectieux majeur aussi bien pour la parturiente que pour le fœtus, elle constitue un facteur de risque de chorioamniotite, de septicémie puerpérale et néonatale. La proteine C réactive est un marqueur biologique largement utilisé dans la détection des infections maternofoetales, en particulier dans le diagnostic précoce de la chorioamniotite en l'absence de signes cliniques d'infection. L’objectif de cette étude est d’évaluer le rôle de la CRP maternelle dans le diagnostic de chorioamniotite, et de la corréler à la prédiction de l’infection néonatale et revoir ainsi les arguments concernant son utilité. Matériels et méthodes: Il s’agit d’une étude rétrospective portant sur des patientes colligées à l’unité Kangourou à la maternité Souissi de Rabat entre mars 2018 et octobre 2018 incluant toutes les parturiente ayant accouché par voie basse d’un nouveau-né asymptomatique dans un contexte de RPM. Une surveillance clinique et biologique notamment par la protéine C réactive de la maman et du nouveau-né a été effectuée. Résultats: 238 patientes ont été admises au service de kangourou pour accouchement dans un contexte de rupture prématurée des membranes. Dans le groupe de CRP maternelle positive, 8 femmes avaient une chorioamiotite clinique, tandis qu’aucun cas de chorioamniotite clinique n’a été enregisté dans le groupe CRP négative. Le groupe de CRP néonatale positive, toutes les mamans avaient une CRP positive tandis que dans le groupe de CRP néonatale négative 37,6% des femmes avaient une CRP positive avec un P<0.001. Conclusion: Notre étude suggère qu’un taux élevé de CRP maternelle avant l'accouchement est un bon prédicteur de chorioamniotite et d’infection néonatale.
Author Keywords: Infection materno-fœtale, chorioamniotite, CRP, septicémie, rupture prématuré des membranes.
How to Cite this Article
Fatima E Hassouni, Malika Mguil, Fatima Zahra Belkouchi, Nour Mekaoui, and Sabah AMRANI, “Premature rupture of membranes: CRP in predicting maternal-fotal infection,” International Journal of Innovation and Applied Studies, vol. 30, no. 1, pp. 96–102, July 2020.
