[ Facteurs de risque associés à la tuberculose multi résistante dans la zone de santé de Nzanza, PROVINCE du Kongo Central en République Démocratique du Congo ]
Volume 38, Issue 1, November 2022, Pages 18–32
C. Bavenga Bavenga1, H. Mondongo2, A. Umba Mbuzi3, and Nlandu Khonde Alphonse4
1 Faculté de médecine de l’université de Lubumbashi, département de médecine interne, RD Congo
2 Ecole de santé publique de l’université de Lubumbashi, RD Congo
3 Faculté de médecine de l’université de Lubumbashi, service de médecine préventive, RD Congo
4 Institut Supérieur de Techniques Médicales de Tshela (ISTM, TSHELA), RD Congo
Original language: French
Copyright © 2022 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The emergence of drug-resistant tuberculosis is still causing a public health crisis. In low-income countries such as the Democratic Republic of Congo, tuberculosis has not been eradicated and the emergence of the multidrug-resistant form is observed in some countries. The objective of this study was to determine the risk factors that contribute to the emergence of multidrug-resistant tuberculosis in the Nzanza Health Zone in the city of Matadi. This case-control analytical study was conducted over a period from January to March 2020. It concerned all lung tuberculosis patients with positive microscopy with confirmed resistance to rifampicin and isoniazid, between the period from January to December 2019 and who freely consented to participate in the study. Data were collected based on interviews with study participants using a structured questionnaire and based on data from the Central Office of the Nzanza Health Zone. The data were analyzed using EPI INFO 7 and Excel software. The Chi-2 test was used to compare the observed proportions and the strength of the associations between the variables was assessed using the odds ratios (OR) with the significance threshold (p ˂ 0.05). The results of this research found that two factors significantly put patients at risk of multidrug-resistant tuberculosis: lack of knowledge of multidrug-resistant tuberculosis OR (3.636) CI 1,342-9,855) (p= 0.011) and alcohol consumption OR (3.61) (CI [1.29 - 10.07]) (p = 0.012). Our study sufficiently demonstrates that multidrug-resistant tuberculosis still represents a major public health problem in some regions of the world and more particularly in the Nzanza Health Zone in the City of Matadi in the Democratic Republic of Congo. However, the emergence of multidrug-resistant tuberculosis could be prevented by implementing community-based awareness strategies.
Author Keywords: factors, risk, tuberculosis, multidrug-resistant, health zone.
Volume 38, Issue 1, November 2022, Pages 18–32
C. Bavenga Bavenga1, H. Mondongo2, A. Umba Mbuzi3, and Nlandu Khonde Alphonse4
1 Faculté de médecine de l’université de Lubumbashi, département de médecine interne, RD Congo
2 Ecole de santé publique de l’université de Lubumbashi, RD Congo
3 Faculté de médecine de l’université de Lubumbashi, service de médecine préventive, RD Congo
4 Institut Supérieur de Techniques Médicales de Tshela (ISTM, TSHELA), RD Congo
Original language: French
Copyright © 2022 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The emergence of drug-resistant tuberculosis is still causing a public health crisis. In low-income countries such as the Democratic Republic of Congo, tuberculosis has not been eradicated and the emergence of the multidrug-resistant form is observed in some countries. The objective of this study was to determine the risk factors that contribute to the emergence of multidrug-resistant tuberculosis in the Nzanza Health Zone in the city of Matadi. This case-control analytical study was conducted over a period from January to March 2020. It concerned all lung tuberculosis patients with positive microscopy with confirmed resistance to rifampicin and isoniazid, between the period from January to December 2019 and who freely consented to participate in the study. Data were collected based on interviews with study participants using a structured questionnaire and based on data from the Central Office of the Nzanza Health Zone. The data were analyzed using EPI INFO 7 and Excel software. The Chi-2 test was used to compare the observed proportions and the strength of the associations between the variables was assessed using the odds ratios (OR) with the significance threshold (p ˂ 0.05). The results of this research found that two factors significantly put patients at risk of multidrug-resistant tuberculosis: lack of knowledge of multidrug-resistant tuberculosis OR (3.636) CI 1,342-9,855) (p= 0.011) and alcohol consumption OR (3.61) (CI [1.29 - 10.07]) (p = 0.012). Our study sufficiently demonstrates that multidrug-resistant tuberculosis still represents a major public health problem in some regions of the world and more particularly in the Nzanza Health Zone in the City of Matadi in the Democratic Republic of Congo. However, the emergence of multidrug-resistant tuberculosis could be prevented by implementing community-based awareness strategies.
Author Keywords: factors, risk, tuberculosis, multidrug-resistant, health zone.
Abstract: (french)
L’émergence de la tuberculose pharmaco résistante est toujours à l’origine d’une crise de santé publique. Dans les pays à faible revenu à l’instar de la République Démocratique du Congo, la tuberculose n’a pas été éradiquée et il s’observe dans certaines contrées, l’émergence de la forme multi résistante. L’objectif de cette étude était de déterminer les facteurs de risque qui contribuent à l’émergence de la tuberculose multi-résistante dans la Zone de Santé de Nzanza dans la ville de Matadi. Cette étude analytique de type cas témoins a été menée sur une période allant de janvier à mars 2020. Elle a concerné tous les malades tuberculeux pulmonaires à microscopie positive avec résistance confirmée à la rifampicine et à l’isoniazide, entre la période de janvier à décembre 2019 et ayant consenti librement de participer à l’étude. Les données ont été collectées sur base des entrevues menées auprès des participants à l’étude à l’aide d’un questionnaire structuré et sur la base des données du Bureau central de la Zone de Santé de Nzanza. Les données ont été analysées en utilisant le logiciel EPI INFO 7 et Excel. Le test de Chi-2 a été utilisé pour comparer les proportions observées et la force des associations entre les variables a été évaluée grâce aux odds ratios (OR) avec le seuil de signification (p ˂ 0,05). Les résultats de cette recherche ont trouvé que deux facteurs exposaient significativement les patients au risque de la tuberculose multi résistante, il s’agit de la méconnaissance de la tuberculose multi résistante OR (3,636) IC 1,342-9,855) (p= 0,011) et la consommation d’alcool OR (3,61) (IC [1,29 - 10,07]) (p = 0,012). Notre étude démontre à suffisance que la tuberculose multi-résistante représente encore un problème majeur de santé publique dans certaines régions du monde et plus particulièrement à la Zone de Santé de Nzanza dans la Ville de Matadi en République Démocratique du Congo. L’émergence de la tuberculose multi résistante pourrait pourtant être évitée par la mise en place des stratégies de sensibilisation communautaire.
Author Keywords: facteurs, risque, tuberculose, multi résistante, zone de santé.
How to Cite this Article
C. Bavenga Bavenga, H. Mondongo, A. Umba Mbuzi, and Nlandu Khonde Alphonse, “Risk factors associated with multidrug-resistant tuberculosis in the health zone of Nzanza, PROVINCE of Kongo Central in the Democratic Republic of Congo,” International Journal of Innovation and Applied Studies, vol. 38, no. 1, pp. 18–32, November 2022.
