Volume 44, Issue 3, January 2025, Pages 770–778
Longin Justin Clair BONAZABA MILANDOU1, Célestine NKOUNKOU LOUMPANGOU2, Arnold Murphy ELOUMA NDINGA3, Hélène CARREYRE4, Adolphe Christian NGAKEGNI-LIMBILI5, Jean-Maurille OUAMBA6, and Sébastien THIBAUDEAU7
1 Unité de Chimie du Végétal et de la Vie, Faculté des Sciences et Techniques, Université Marien N’GOUABI, B.P. 69, Brazzaville, Republic of the Congo
2 Unité de Chimie du Végétal et de la Vie, Faculté des Sciences et Techniques, Université Marien N’GOUABI, B.P. 69, Brazzaville, Republic of the Congo
3 Unité de Chimie du Végétal et de la Vie, Faculté des Sciences et Techniques, Université Marien N’GOUABI, B.P. 69, Brazzaville, Republic of the Congo
4 Equipe Superacides-Groupe Synthèse Organique, IC2MP-UMR CNRS 7582, Université de Poitiers, 4 Rue Michel Brunet TSA 51106, 86073 Poitiers Cedex 9, France
5 Unité de Chimie du Végétal et de la Vie, Faculté des Sciences et Techniques, Université Marien N’GOUABI, B.P. 69, Brazzaville, Republic of the Congo
6 Unité de Chimie du Végétal et de la Vie (UC2V), Faculté des Sciences et Techniques, Université Marien Ngouabi, BP 69, Brazzaville, Republic of the Congo
7 Equipe Superacides-Groupe Synthèse Organique, IC2MP-UMR CNRS 7582, Université de Poitiers, 4 Rue Michel Brunet TSA 51106, 86073 Poitiers Cedex 9, France
Original language: English
Copyright © 2025 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
In order to promote congolese plants with antihypertensive properties, two hypotensive (antihypertensive) extracts of Trema orientalis B. leaves were selected in order to know their flavonoid profiles. Therefore, these extracts were prepared and underwent bioguided fractionations until the isolation of the compounds on silica gel. These ethanolic and aqueous extracts presented similar characteristics (appearance, solubility in polar solvents, color of spots at UV 365 nm, frontal ratio). Five compounds were isolated from these extracts of Trema orientalis leaves. The analytical data of these compounds show a similarity of physical and chemical characteristics. These compounds presented in NMR1H the same basic structure of the flavonoid type, 5,7,4’-trihydroxyl-2,3-dihydroflavonol (Kaempferol) or 5,7,4’-trihydroxyl-2,3-dihydroisoflavonol of gross formula C15H12O6 and differ on their osidic part. Therefore, the definitive structural determination of these compounds must be confirmed by other more in-depth analyses. They will allow to valorize this plant by the production of phytoproducts rich in flavonoids antihypertensive and with oxidizing power.
Author Keywords: flavonoid profile, trema orientalis, antihypertensive extracts, kaempferol, bioguided fractionation.
Longin Justin Clair BONAZABA MILANDOU1, Célestine NKOUNKOU LOUMPANGOU2, Arnold Murphy ELOUMA NDINGA3, Hélène CARREYRE4, Adolphe Christian NGAKEGNI-LIMBILI5, Jean-Maurille OUAMBA6, and Sébastien THIBAUDEAU7
1 Unité de Chimie du Végétal et de la Vie, Faculté des Sciences et Techniques, Université Marien N’GOUABI, B.P. 69, Brazzaville, Republic of the Congo
2 Unité de Chimie du Végétal et de la Vie, Faculté des Sciences et Techniques, Université Marien N’GOUABI, B.P. 69, Brazzaville, Republic of the Congo
3 Unité de Chimie du Végétal et de la Vie, Faculté des Sciences et Techniques, Université Marien N’GOUABI, B.P. 69, Brazzaville, Republic of the Congo
4 Equipe Superacides-Groupe Synthèse Organique, IC2MP-UMR CNRS 7582, Université de Poitiers, 4 Rue Michel Brunet TSA 51106, 86073 Poitiers Cedex 9, France
5 Unité de Chimie du Végétal et de la Vie, Faculté des Sciences et Techniques, Université Marien N’GOUABI, B.P. 69, Brazzaville, Republic of the Congo
6 Unité de Chimie du Végétal et de la Vie (UC2V), Faculté des Sciences et Techniques, Université Marien Ngouabi, BP 69, Brazzaville, Republic of the Congo
7 Equipe Superacides-Groupe Synthèse Organique, IC2MP-UMR CNRS 7582, Université de Poitiers, 4 Rue Michel Brunet TSA 51106, 86073 Poitiers Cedex 9, France
Original language: English
Copyright © 2025 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
In order to promote congolese plants with antihypertensive properties, two hypotensive (antihypertensive) extracts of Trema orientalis B. leaves were selected in order to know their flavonoid profiles. Therefore, these extracts were prepared and underwent bioguided fractionations until the isolation of the compounds on silica gel. These ethanolic and aqueous extracts presented similar characteristics (appearance, solubility in polar solvents, color of spots at UV 365 nm, frontal ratio). Five compounds were isolated from these extracts of Trema orientalis leaves. The analytical data of these compounds show a similarity of physical and chemical characteristics. These compounds presented in NMR1H the same basic structure of the flavonoid type, 5,7,4’-trihydroxyl-2,3-dihydroflavonol (Kaempferol) or 5,7,4’-trihydroxyl-2,3-dihydroisoflavonol of gross formula C15H12O6 and differ on their osidic part. Therefore, the definitive structural determination of these compounds must be confirmed by other more in-depth analyses. They will allow to valorize this plant by the production of phytoproducts rich in flavonoids antihypertensive and with oxidizing power.
Author Keywords: flavonoid profile, trema orientalis, antihypertensive extracts, kaempferol, bioguided fractionation.
How to Cite this Article
Longin Justin Clair BONAZABA MILANDOU, Célestine NKOUNKOU LOUMPANGOU, Arnold Murphy ELOUMA NDINGA, Hélène CARREYRE, Adolphe Christian NGAKEGNI-LIMBILI, Jean-Maurille OUAMBA, and Sébastien THIBAUDEAU, “Flavonoid profile of two antihypertensive extracts of Trema orientalis Blume leaves (Cannabaceae),” International Journal of Innovation and Applied Studies, vol. 44, no. 3, pp. 770–778, January 2025.
