Volume 8, Issue 2, September 2014, Pages 503–514
Abdeltif Errouagui1, Houda Benrahma2, Hicham Charoute3, Noureddine Ghalim4, AbdelHamid Barakat5, Mostafa Kandil6, and Hassan Rouba7
1 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
2 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
3 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
4 Laboratoire de biochimie, centre de biologie médical, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
5 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
6 Laboratoire des Sciences Anthropogenetiques et Pathologiques, Faculté des Sciences, Université Chouaib Doukkali, ElJadida, Maroc
7 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
Original language: English
Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Vitamin D receptor (VDR) gene is recognized as candidate gene for susceptibility to Type 2 diabetes mellitus (T2DM). The goal of this study was to search the eventual association between VDR gene polymorphisms and T2DM in Moroccans patients. Materials and Methods: 176 patients with T2DM and 177 Healthy controls from the Moroccans population were recruited. Bsm-I(rs1544410), Fok-I(rs10735810) and Apa-I(rs7975232) SNPs of the VDR gene were determined PCR-RFLP. A Vitamin D level was determined using ELISA. Results: The prevalence of Vitamin D inadequancy is higher significantly in patients with T2DM than in the controls subjects. There was a strong association between fok-I polymorphisms with T2DM (OR = 0,35, 95% CI = 0.14
Author Keywords: Diabete type 2, polymorphism, VDR, vitamin D receptor Bsm-I, Fok-I, Apa-I.
Abdeltif Errouagui1, Houda Benrahma2, Hicham Charoute3, Noureddine Ghalim4, AbdelHamid Barakat5, Mostafa Kandil6, and Hassan Rouba7
1 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
2 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
3 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
4 Laboratoire de biochimie, centre de biologie médical, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
5 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
6 Laboratoire des Sciences Anthropogenetiques et Pathologiques, Faculté des Sciences, Université Chouaib Doukkali, ElJadida, Maroc
7 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
Original language: English
Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Vitamin D receptor (VDR) gene is recognized as candidate gene for susceptibility to Type 2 diabetes mellitus (T2DM). The goal of this study was to search the eventual association between VDR gene polymorphisms and T2DM in Moroccans patients. Materials and Methods: 176 patients with T2DM and 177 Healthy controls from the Moroccans population were recruited. Bsm-I(rs1544410), Fok-I(rs10735810) and Apa-I(rs7975232) SNPs of the VDR gene were determined PCR-RFLP. A Vitamin D level was determined using ELISA. Results: The prevalence of Vitamin D inadequancy is higher significantly in patients with T2DM than in the controls subjects. There was a strong association between fok-I polymorphisms with T2DM (OR = 0,35, 95% CI = 0.14
Author Keywords: Diabete type 2, polymorphism, VDR, vitamin D receptor Bsm-I, Fok-I, Apa-I.
How to Cite this Article
Abdeltif Errouagui, Houda Benrahma, Hicham Charoute, Noureddine Ghalim, AbdelHamid Barakat, Mostafa Kandil, and Hassan Rouba, “Relationship between Vitamin D Receptor (VDR) Gene Polymorphisms and susceptibility to Type 2 Diabetes Mellitus in Moroccans population,” International Journal of Innovation and Applied Studies, vol. 8, no. 2, pp. 503–514, September 2014.
