[ Contrôle Pharmaceutique des marques de comprimés d’ibuprofène vendus dans les secteurs formel et informel au Cameroun ]
Volume 17, Issue 1, July 2016, Pages 284–290
Emmanuel NNANGA NGA1, Stéphanie TAMDEM GUETCHUENG2, Marie Rosine MANGA3, Lazare SIDJUI SIDJUI4, and Emmanuel A. MPONDO MPONDO5
1 Department of galenical Pharmacy and pharmaceutical legislation, Faculty of Medicine and Biological Sciences, the University of Yaoundé I. PO. Box: 1364, Yaoundé,Department of Pharmaceutical Science, Faculty of Medicine and Pharmaceutical Science ; the University of Douala, PO. Box : 2701, Douala, Institute of Medical Research and Medicinal Plants Studies, PO.Box:6163. Yaoundé, Cameroon
2 Laboratoire de Technologie Pharmaceutique, Institut de Recherches Médicales et d’études des plantes Médicinales (IMPM), B.P. : 6163 Yaoundé, Cameroun
3 Département de Sciences Pharmaceutiques, Faculté de médecine et des sciences pharmaceutiques, Université de Douala, B.P. : 2701 Douala, Cameroun
4 Laboratoire de Technologie Pharmaceutique, Institut de Recherches Médicales et d’études des plantes Médicinales (IMPM), B.P. : 6163 Yaoundé, Cameroun
5 Department of Pharmaceutical Science, Faculty of Medicine and Pharmaceutical Science, University of Douala, PO. Box : 2701, Douala, Cameroun
Original language: French
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The proliferation of illicit drug markets facilitate the flow of doubtful quality products of uncertain origin to the most disadvantaged populations. The consumption of counterfeit medicines that do not meet international standards can explain the repeated treatment failures, the development of tolerance or even addiction to drug observed after taking generic drugs. High consumption of compressed ibuprofen, second most consumed analgesic after paracetamol led us to a comparative study of physicochemical and dosage parameters of the generic pill ibuprofen 400 mg sold in the formal and informal market in Douala according to international pharmacopoeia. The results show that non-normalised medicines are present both in the formal and in the informal circuit. Each of the circuits presented a compliance rate of about 80%. Moreover, the presence of the same batch of tablet, from the same laboratory both in the formal and in the informal circuit would be a proof that the informal market of drugs "gazon" supply is assured by both the smuggling and the formal distribution sector. It is imperative that Governments in countries such as Cameroon through health and safety officers take radical decisions to control the quality, stability and efficiency of drugs introduced in their countries.
Author Keywords: Ibuprofen, "gazon", formal circuit, smuggling, international standard, treatment failure.
Volume 17, Issue 1, July 2016, Pages 284–290
Emmanuel NNANGA NGA1, Stéphanie TAMDEM GUETCHUENG2, Marie Rosine MANGA3, Lazare SIDJUI SIDJUI4, and Emmanuel A. MPONDO MPONDO5
1 Department of galenical Pharmacy and pharmaceutical legislation, Faculty of Medicine and Biological Sciences, the University of Yaoundé I. PO. Box: 1364, Yaoundé,Department of Pharmaceutical Science, Faculty of Medicine and Pharmaceutical Science ; the University of Douala, PO. Box : 2701, Douala, Institute of Medical Research and Medicinal Plants Studies, PO.Box:6163. Yaoundé, Cameroon
2 Laboratoire de Technologie Pharmaceutique, Institut de Recherches Médicales et d’études des plantes Médicinales (IMPM), B.P. : 6163 Yaoundé, Cameroun
3 Département de Sciences Pharmaceutiques, Faculté de médecine et des sciences pharmaceutiques, Université de Douala, B.P. : 2701 Douala, Cameroun
4 Laboratoire de Technologie Pharmaceutique, Institut de Recherches Médicales et d’études des plantes Médicinales (IMPM), B.P. : 6163 Yaoundé, Cameroun
5 Department of Pharmaceutical Science, Faculty of Medicine and Pharmaceutical Science, University of Douala, PO. Box : 2701, Douala, Cameroun
Original language: French
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The proliferation of illicit drug markets facilitate the flow of doubtful quality products of uncertain origin to the most disadvantaged populations. The consumption of counterfeit medicines that do not meet international standards can explain the repeated treatment failures, the development of tolerance or even addiction to drug observed after taking generic drugs. High consumption of compressed ibuprofen, second most consumed analgesic after paracetamol led us to a comparative study of physicochemical and dosage parameters of the generic pill ibuprofen 400 mg sold in the formal and informal market in Douala according to international pharmacopoeia. The results show that non-normalised medicines are present both in the formal and in the informal circuit. Each of the circuits presented a compliance rate of about 80%. Moreover, the presence of the same batch of tablet, from the same laboratory both in the formal and in the informal circuit would be a proof that the informal market of drugs "gazon" supply is assured by both the smuggling and the formal distribution sector. It is imperative that Governments in countries such as Cameroon through health and safety officers take radical decisions to control the quality, stability and efficiency of drugs introduced in their countries.
Author Keywords: Ibuprofen, "gazon", formal circuit, smuggling, international standard, treatment failure.
Abstract: (french)
La multiplication des marchés illicites de médicaments facilite la circulation de produits de qualité douteuse et d’origine incertaine à destination des populations les plus désavantagées. La consommation de médicaments contrefaits ne répondant pas aux normes internationales expliquerait les échecs thérapeutiques répétitifs, le développement de tolérance ou même de dépendance à un médicament observé suite à la prise de médicaments génériques. La consommation élevée de l’ibuprofène comprimé, deuxième analgésique le plus consommé après le paracétamol nous a menés à une étude comparative des paramètres physico-chimiques et galéniques de l’ibuprofène comprimé générique dosé à 400 mg vendus dans le circuit formel et informel dans la ville de Douala suivant la pharmacopée internationale. Les résultats montrent que les médicaments hors normes sont présents aussi bien dans le circuit formel que dans le circuit informel. Chacun des circuits présentant un taux de conformité de l’ordre de 80%. Par ailleurs la présence du même lot de comprimé aussi bien dans le circuit formel que dans le circuit informel serait une preuve que l’approvisionnement de marché informel de médicaments « gazon » est assuré à la fois par la contrebande et le secteur formel de distribution. Il est impératif que Les gouvernements des pays tel que le Cameroun par le biais des agents de santé et de sécurité prennent des décisions radicales afin de contrôler la qualité, la stabilité et l’efficacité des médicaments introduits dans leurs pays.
Author Keywords: Ibuprofène, "gazon", circuit formel, contrebande, norme internationale, échec thérapeutique.
How to Cite this Article
Emmanuel NNANGA NGA, Stéphanie TAMDEM GUETCHUENG, Marie Rosine MANGA, Lazare SIDJUI SIDJUI, and Emmanuel A. MPONDO MPONDO, “Pharmaceutical control of ibuprofen tablets brands sold in the formal and informal sectors in Cameroon,” International Journal of Innovation and Applied Studies, vol. 17, no. 1, pp. 284–290, July 2016.
