[ Synthèse de nouveaux dérivés pyridazinones assistée par Micro-ondes en milieu sec en le comparant au chauffage classique (chauffage à reflux) ]
Volume 18, Issue 2, October 2016, Pages 381–387
Ahmad Oubair1 and Rachid Fihi2
1 Département de chimie, Université My Smail Meknes, Faculté des Sciences et Technique, Errachidia, Morocco
2 Département de chimie, Université My Smail Meknes, Faculté des Sciences et Technique, Errachidia, Morocco
Original language: French
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
In this work, we report an efficient protocol containing the technique of microwave oven and its comparison with the conventional method (refluxing) for the synthesis of new derivatives pyridazinones namely 4-(p-alkylbenzylidene)pyridazin-3(2H)-ones. These are obtained by condensation of α-arylidene-γ-butyrolactones precursors and hydrazines in the presence of p-toluene sulfonic acid (PTSA). The structures of these new compounds were identified by spectral methods (1H, 13C NMR and IR).
Author Keywords: α-arylidene-γ-butyrolactone, hydrazine, pyridazinones, microwave, silice.
Volume 18, Issue 2, October 2016, Pages 381–387
Ahmad Oubair1 and Rachid Fihi2
1 Département de chimie, Université My Smail Meknes, Faculté des Sciences et Technique, Errachidia, Morocco
2 Département de chimie, Université My Smail Meknes, Faculté des Sciences et Technique, Errachidia, Morocco
Original language: French
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
In this work, we report an efficient protocol containing the technique of microwave oven and its comparison with the conventional method (refluxing) for the synthesis of new derivatives pyridazinones namely 4-(p-alkylbenzylidene)pyridazin-3(2H)-ones. These are obtained by condensation of α-arylidene-γ-butyrolactones precursors and hydrazines in the presence of p-toluene sulfonic acid (PTSA). The structures of these new compounds were identified by spectral methods (1H, 13C NMR and IR).
Author Keywords: α-arylidene-γ-butyrolactone, hydrazine, pyridazinones, microwave, silice.
Abstract: (french)
Dans ce travail, nous rapportons un protocole efficace contenant la technique du four à micro-ondes et sa comparaison à la méthode classique (chauffage à reflux) pour la synthèse de nouveaux dérivés pyridazinones à savoir 4-(p-alkylbenzylidène)pyridazin-3(2H)-ones. Ces derniers sont obtenus par condensation des précurseurs α-arylidène-γ-butyrolactones et les hydrazines en présence de l’acide p-toluène sulfonique (APTS). Les structures des produits synthétisés ont été établies à l’aide des analyses spectroscopiques, RMN 1H, 13C et IR.
Author Keywords: α-arylidène-γ-lactones, hydrazines, pyridazinones, micro-ondes, silice.
How to Cite this Article
Ahmad Oubair and Rachid Fihi, “Synthesis of new derivatives pyridazinones assisted by Microwave on dry medium comparing it to conventional heating (refluxing),” International Journal of Innovation and Applied Studies, vol. 18, no. 2, pp. 381–387, October 2016.
