Volume 19, Issue 1, January 2017, Pages 1–8
Alina Bogliș1, Andrei George Crauciuc2, Florin Tripon3, Cristina Georgiana Radu4, Smaranda Demian5, Carmen Duicu6, and Claudia Bănescu7
1 Department of Genetics, The University of Medicine and Pharmacy of Tîrgu Mureș, Romania
2 Department of Genetics, The University of Medicine and Pharmacy of Tîrgu Mureș, Romania
3 Department of Genetics, The University of Medicine and Pharmacy of Tîrgu Mureș, Romania
4 The University of Medicine and Pharmacy of Tîrgu Mureș, Romania
5 Hematology Clinic 1, Emergency Clinical County Hospital Tîrgu Mureș, Romania
6 Department of Pediatrics I, The University of Medicine and Pharmacy of Tîrgu Mureș, Romania
7 Department of Genetics, The University of Medicine and Pharmacy of Tîrgu Mureș, Romania
Original language: English
Copyright © 2017 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Polymorphisms of the glutathione S-transferases (GSTs), which are involved in the cellular oxidative and antioxidant mechanisms of the xenobiotic substances and carcinogens, represents a factor that increases the risk of developing cancer. We aimed to determine in a case-control study (82 patients and 152 controls) a possible association between the GSTT1, GSTM1 and GSTP1 gene polymorphisms and susceptibility to non-Hodgkin lymphoma (NHL) in a Romanian population. GTSs genotypes were obtained using the multiplex polymerase chain reaction (PCR) and the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Increased frequencies of the GSTM1 null genotype were observed in the patients (51.22%) with NHL and in controls (56.58%). No associations were observed between GSTP1 Ile/Val + Val/Val and GSTM1 null genotypes and risk of NHL, while an increased risk for GSTT1 null genotype was noticed without statistical significance. We did not find differences for the combined GST gene polymorphisms and risk of NHL between patients and controls. Also, no differences between patients’ demographic and clinical characteristics and GTSs genotypes were detected (p>0.05, for all comparisons). Therefore, our research suggests that GSTM1, GSTT1, and GSTP1 genotypes do not contribute to the risk of developing NHL.
Author Keywords: GSTT1, GSTM1, GSTP1, gene polymorphism, non-Hodgkin lymphoma.
Alina Bogliș1, Andrei George Crauciuc2, Florin Tripon3, Cristina Georgiana Radu4, Smaranda Demian5, Carmen Duicu6, and Claudia Bănescu7
1 Department of Genetics, The University of Medicine and Pharmacy of Tîrgu Mureș, Romania
2 Department of Genetics, The University of Medicine and Pharmacy of Tîrgu Mureș, Romania
3 Department of Genetics, The University of Medicine and Pharmacy of Tîrgu Mureș, Romania
4 The University of Medicine and Pharmacy of Tîrgu Mureș, Romania
5 Hematology Clinic 1, Emergency Clinical County Hospital Tîrgu Mureș, Romania
6 Department of Pediatrics I, The University of Medicine and Pharmacy of Tîrgu Mureș, Romania
7 Department of Genetics, The University of Medicine and Pharmacy of Tîrgu Mureș, Romania
Original language: English
Copyright © 2017 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Polymorphisms of the glutathione S-transferases (GSTs), which are involved in the cellular oxidative and antioxidant mechanisms of the xenobiotic substances and carcinogens, represents a factor that increases the risk of developing cancer. We aimed to determine in a case-control study (82 patients and 152 controls) a possible association between the GSTT1, GSTM1 and GSTP1 gene polymorphisms and susceptibility to non-Hodgkin lymphoma (NHL) in a Romanian population. GTSs genotypes were obtained using the multiplex polymerase chain reaction (PCR) and the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Increased frequencies of the GSTM1 null genotype were observed in the patients (51.22%) with NHL and in controls (56.58%). No associations were observed between GSTP1 Ile/Val + Val/Val and GSTM1 null genotypes and risk of NHL, while an increased risk for GSTT1 null genotype was noticed without statistical significance. We did not find differences for the combined GST gene polymorphisms and risk of NHL between patients and controls. Also, no differences between patients’ demographic and clinical characteristics and GTSs genotypes were detected (p>0.05, for all comparisons). Therefore, our research suggests that GSTM1, GSTT1, and GSTP1 genotypes do not contribute to the risk of developing NHL.
Author Keywords: GSTT1, GSTM1, GSTP1, gene polymorphism, non-Hodgkin lymphoma.
How to Cite this Article
Alina Bogliș, Andrei George Crauciuc, Florin Tripon, Cristina Georgiana Radu, Smaranda Demian, Carmen Duicu, and Claudia Bănescu, “No association between GSTT1, GSTM1, and GSTP1 gene polymorphism and risk of non-Hodgkin lymphoma in a population from Romania,” International Journal of Innovation and Applied Studies, vol. 19, no. 1, pp. 1–8, January 2017.
