[ Évaluation de la toxicité aiguë des feuilles d’Albizia adianthifolia S. et de Combretum molle R. ]
Volume 38, Issue 2, December 2022, Pages 428–442
Mukadi Kanku Obed1 and Fimbo Ntenta Daniel2
1 Assistant, Institut Supérieur Pédagogique de Kolwezi, B.P 300, Kolwezi, RD Congo
2 Chargé d’enseignement, Institut Supérieur Pédagogique de Lubumbashi, B.P 1796, Lubumbashi, RD Congo
Original language: French
Copyright © 2022 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The use of traditional herbal recipes is increasing increasingly all over the eath. These plants, use in the treatment of various pathologies, are for the most part of source of sometimes tragic and fatal poisoning. The objective of this study was to evaluate the acute toxicity of the leaves of Albizia adianthifolia S. and Combretum molle R. plants frequently used un traditional medicine in the city of Lubumbashi, respectively for treatment of eye diseases, against diabetes and as an anthelmintic. The assessment of acute toxicity was carried out by observing certain clinical signs of toxicity. The assay of the biochemical parameters namely urea, creatinine, albumin, bilirubin was also carried out. The aqueous extracts of macerated leaves of Albizia adianthifolia S. and Combretum molle R. as plant material were administered orally to male guinea pigs during the experiment at three doses (1000, 2000 and 3000 mg/kg). Renal, hepatic and cardiac toxicity as well as haematologic toxicity were observed by the disturbance of the parameters analyzed, including loss of hair in the abdomen and back, aggressiveness, chills, abnormal breathing, eating disorder, isolation and difficulty in locomotion. In conclusion, the use of Albizia adianthifolia S. at doses greater than 1g/kg would be toxic for guinea pigs although the LD50 is above 3 kg/ kg and with regard to the use of Combretum molle, it can be classified in the categoty of low toxic plants.
Author Keywords: plants, poisoining, signs, disturbance, guinea pigs, Lubumbashi.
Volume 38, Issue 2, December 2022, Pages 428–442
Mukadi Kanku Obed1 and Fimbo Ntenta Daniel2
1 Assistant, Institut Supérieur Pédagogique de Kolwezi, B.P 300, Kolwezi, RD Congo
2 Chargé d’enseignement, Institut Supérieur Pédagogique de Lubumbashi, B.P 1796, Lubumbashi, RD Congo
Original language: French
Copyright © 2022 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The use of traditional herbal recipes is increasing increasingly all over the eath. These plants, use in the treatment of various pathologies, are for the most part of source of sometimes tragic and fatal poisoning. The objective of this study was to evaluate the acute toxicity of the leaves of Albizia adianthifolia S. and Combretum molle R. plants frequently used un traditional medicine in the city of Lubumbashi, respectively for treatment of eye diseases, against diabetes and as an anthelmintic. The assessment of acute toxicity was carried out by observing certain clinical signs of toxicity. The assay of the biochemical parameters namely urea, creatinine, albumin, bilirubin was also carried out. The aqueous extracts of macerated leaves of Albizia adianthifolia S. and Combretum molle R. as plant material were administered orally to male guinea pigs during the experiment at three doses (1000, 2000 and 3000 mg/kg). Renal, hepatic and cardiac toxicity as well as haematologic toxicity were observed by the disturbance of the parameters analyzed, including loss of hair in the abdomen and back, aggressiveness, chills, abnormal breathing, eating disorder, isolation and difficulty in locomotion. In conclusion, the use of Albizia adianthifolia S. at doses greater than 1g/kg would be toxic for guinea pigs although the LD50 is above 3 kg/ kg and with regard to the use of Combretum molle, it can be classified in the categoty of low toxic plants.
Author Keywords: plants, poisoining, signs, disturbance, guinea pigs, Lubumbashi.
Abstract: (french)
L’utilisation des recettes traditionnelles à base des plantes accroît de plus en plus sur toute l’étendue de la terre. Ces plantes exploitées dans la prise en charge des pathologies diverses sont pour la plupart source d’intoxications parfois tragiques et mortelles. Cette étude s’est fixé comme objectif, l’évaluation de la toxicité aigüe des feuilles d’Albizia adianthifolia S. et de Combretum molle R. plantes utilisées fréquemment en médecine traditionnelle dans la ville de Lubumbashi respectivement pour le traitement d’affections oculaires, contre le diabète et comme vermifuge. L’évaluation de la toxicité aiguë a été réalisée par l’observation de certains signes cliniques de toxicité. Le dosage des paramètres biochimiques à savoir l’urée, la créatinine, albumine, bilirubine a été également réalisé. Les extraits aqueux de macéré des feuilles d’Albizia adianthifolia et de Combretum molle comme matériel végétal ont été administrés per os aux cobayes mâles lors de l’expérimentation en raison de trois doses différentes (1000, 2000 et 3000 mg/kg). Une toxicité rénale, hépatique, cardiaque ainsi qu’une toxicité hématologique ont été observées par la perturbation des paramètres analysés. Certains symptômes de toxicité ont été observés, notamment la perte des poils au niveau de l’abdomen et au dos, agressivité, frissons, respiration anormale, trouble alimentaire, isolement et difficulté de locomotion. En conclusion, l’usage d’Albizia adianthifolia aux doses supérieures à 1g/kg serait toxique pour le cobaye bien que la DL50 soit au-delà de 3g/kg et en ce qui concerne l’usage de Combretum molle, elle peut être classée dans la catégorie des plantes faiblement toxiques.
Author Keywords: plantes, intoxication, signes, perturbation, cobayes, Lubumbashi.
How to Cite this Article
Mukadi Kanku Obed and Fimbo Ntenta Daniel, “Assessment of the acute toxicity of leaves of Albizia adianthifolia S. and Combretum molle R.,” International Journal of Innovation and Applied Studies, vol. 38, no. 2, pp. 428–442, December 2022.
