[ Evaluation de la toxicité subaiguë et des effets d’un extrait aqueux de Justicia flava (forsk) Vahl (Acanthaceae) sur les marqueurs sanguins biochimiques et les tissus rénaux ]
Volume 44, Issue 1, November 2024, Pages 154–161
Djè Kouamé Wenceslas Kouame1, Kouadio Frédéric N’Dia2, Oussou N’Guessan Jean-Baptiste3, Kouakou Léandre Kouakou4, and Doumbia Idrissa5
1 Unité de Formation et de Recherche-Ingénierie, Agronomique, Forestière et environnementale (UFR-IAFE), Université Polytechnique de Man (UP-Man), Côte d’Ivoire
2 Laboratoire de Physiologie, Pharmacologie et Pharmacopée (L3P). Unité de Formation et de Recherche-Sciences de la Nature (UFR-SN), Université Nangui ABROGOUA (UNA), 02 BP 801 Abidjan 02, Côte d’Ivoire
3 Laboratory of Physiology, Pharmacology and Pharmacopoeia - Nangui Abrogoua University, 02 BP 801 Abidjan 02, Côte d’Ivoire
4 Laboratoire de Physiologie, Pharmacologie et Pharmacopée (L3P). Unité de Formation et de Recherche-Sciences de la Nature (UFR-SN), Université Nangui ABROGOUA (UNA), 02 BP 801 Abidjan 02, Côte d’Ivoire
5 Food and Bioproducts Processes Laboratory, Agronomic, Forestry and Environmental Engineering Department, University of Man, PO Box 20 Man, Côte d’Ivoire
Original language: French
Copyright © 2024 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Justicia flava is a plant commonly used because of its several pharmacological properties. In this work seventy (70) rats were divided into 7 groups of 10 animals consisting of five males and five females each in order to check the subacute toxicity and the effects on the kidney of this plant. To do this, the animals were administered daily, orally and for 28 days with doses of 125, 250, 500 and 1000 mg/kg bw of the aqueous extract of J. flava. The results showed that this extract was non-toxic on renal function. At these doses, the extract did not cause any significant variation in serum levels of electrolytes (chlorine, sodium, calcium, and potassium). Likewise, renal markers like urea and creatinine showed no significant variation. No structural abnormality in the kidney tissues of treated rats compared to control rats was revealed during this experiment. In conclusion, the aqueous extract of J. flava is safe and without toxic effects for the kidney.
Author Keywords: Justicia flava, toxicity, kidney, biochemistry, histology.
Volume 44, Issue 1, November 2024, Pages 154–161
Djè Kouamé Wenceslas Kouame1, Kouadio Frédéric N’Dia2, Oussou N’Guessan Jean-Baptiste3, Kouakou Léandre Kouakou4, and Doumbia Idrissa5
1 Unité de Formation et de Recherche-Ingénierie, Agronomique, Forestière et environnementale (UFR-IAFE), Université Polytechnique de Man (UP-Man), Côte d’Ivoire
2 Laboratoire de Physiologie, Pharmacologie et Pharmacopée (L3P). Unité de Formation et de Recherche-Sciences de la Nature (UFR-SN), Université Nangui ABROGOUA (UNA), 02 BP 801 Abidjan 02, Côte d’Ivoire
3 Laboratory of Physiology, Pharmacology and Pharmacopoeia - Nangui Abrogoua University, 02 BP 801 Abidjan 02, Côte d’Ivoire
4 Laboratoire de Physiologie, Pharmacologie et Pharmacopée (L3P). Unité de Formation et de Recherche-Sciences de la Nature (UFR-SN), Université Nangui ABROGOUA (UNA), 02 BP 801 Abidjan 02, Côte d’Ivoire
5 Food and Bioproducts Processes Laboratory, Agronomic, Forestry and Environmental Engineering Department, University of Man, PO Box 20 Man, Côte d’Ivoire
Original language: French
Copyright © 2024 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Justicia flava is a plant commonly used because of its several pharmacological properties. In this work seventy (70) rats were divided into 7 groups of 10 animals consisting of five males and five females each in order to check the subacute toxicity and the effects on the kidney of this plant. To do this, the animals were administered daily, orally and for 28 days with doses of 125, 250, 500 and 1000 mg/kg bw of the aqueous extract of J. flava. The results showed that this extract was non-toxic on renal function. At these doses, the extract did not cause any significant variation in serum levels of electrolytes (chlorine, sodium, calcium, and potassium). Likewise, renal markers like urea and creatinine showed no significant variation. No structural abnormality in the kidney tissues of treated rats compared to control rats was revealed during this experiment. In conclusion, the aqueous extract of J. flava is safe and without toxic effects for the kidney.
Author Keywords: Justicia flava, toxicity, kidney, biochemistry, histology.
Abstract: (french)
Justicia flava est une plante communément utilisée pour ses nombreuses propriétés pharmacologiques. Dans cette étude, soixante-dix (70) rats ont été divisés en 7 lots de 10 animaux constitués de cinq mâles et cinq femelles chacun pour vérifier la toxicité subaiguë et les effets sur le rein de cette plante. Pour ce faire, Les animaux ont été administrés quotidiennement, par voie orale et pendant 28 jours avec les doses de 125, 250, 500 et 1000 mg/kg pc de l’extrait aqueux de J. flava. Les résultats ont montré que cet extrait était non toxique sur la fonction rénale A ces doses, l’extrait n’avait provoqué aucune variation significative des taux sériques des électrolytes (chlore, sodium, calcium, et potassium). De même, les marqueurs rénaux comme l’urée et la créatinine n’ont présenté aucune variation significative. Aucune anomalie de structures au niveau des tissus rénaux des rats traités par rapport aux rats témoins n’a été révélée au cours de cette expérimentation. En conclusion, l’extrait aqueux de J. flava est sûr et sans effet toxique pour le rein.
Author Keywords: Justicia flava, toxicité, rein, biochimie, histologie.
How to Cite this Article
Djè Kouamé Wenceslas Kouame, Kouadio Frédéric N’Dia, Oussou N’Guessan Jean-Baptiste, Kouakou Léandre Kouakou, and Doumbia Idrissa, “Evaluation of the subacute toxicity and effects of an aqueous extract of Justicia flava (forsk) Vahl (Acanthaceae) on blood biochemical markers and renal tissues,” International Journal of Innovation and Applied Studies, vol. 44, no. 1, pp. 154–161, November 2024.
