Pearl millet is the first cereal produced and consumed in Niger. However, its production hampered by several types of constraints including pearl millet downy mildew. The objective of this study is to assess the effect of variety + mineral fertilizer and variety + seed treatment combinations for the integrated management of pearl millet downy mildew. A Split-split-plot device with three factors (variety, mineral fertilizer and fungicide) is used. Data on the incidence and the severity of downy mildew are collected and analyzed. The incidence of the disease reached 8.13 ± 2.24% and 5.24 ± 1.69% after application of 2 g of DAP and 6 g of N15P15K15 per packet respectively compared with 12.41 ± 2.43% for the control. The application of N15P15K15 has more effect with ICRI-Tabi and that of DAP with ICMV-IS 89305. The severity of the disease went from 9.65% for the control at 5.27% after treatment of seeds with Apron Star42W.This effect is more remarkable at the level of HKP and ICRI-Tabi. The study has shown that the application of mineral fertilizer to seedlings reduces the infection of pearl millet downy mildew. In addition, N15P15K15 has more effect than DAP. Likewise, seed treatment with Apron Star42W significantly reduces the attack of the disease.