Laboratoire d’Epidémiologie, Recherche Clinique et Santé Communautaire, Faculté de Médecine et de Pharmacie de Fès, Université Sidi Mohamed Ben Abdellah, Fès, Morocco
Systemic Lupus Erythematosus (SLE) patients may have arthritis in early stages of the disease. This study aims to investigate the prevalence of anti-CCP in SLE patients from Morocco and its association with HLA class II alleles. Anti-cyclic citrullinated peptide antibodies (Anti-CCP) were measured using ELISA in 88 SLE patients with and without arthritis. Levels ≥ 25 units/ ml defined a positive test of anti-CCP antibodies. Positive anti-CCP was detected in 8 % of SLE patients whose 85.71% % with arthritis and 14.28% without arthritis. The mean titer of anti-CCP antibodies in the SLE group was 83.75 U/ml. HLA class II alleles typing was performed by polymerase chain reaction-sequence-specific primers (PCR-SSP). We found an increase of HLA-DRB1*04 frequency and decrease of DRB1*07 frequency in SLE patients with anti-CCP positive. In the Moroccan population we demonstrated the presence of high titer of anti-CCP in SLE. Results from our study also identified the frequency of HLA-DRB1*04 allele is increased in SLE with anti-CCP positive.
This cross-sectional study aims to identify health behaviors among adolescents engaged in team sport in Taza, Morocco. The whole sample includes 512 adolescents aged between 13 and 20 years old (Girls = 45.5% and Boys = 54.5%). Participation in team sport was estimated to 61.1%. Results revealed that engagement in team sport is not associated with healthy behaviors of adolescents. Hence, more adolescents in team sport adopt violent behaviors. Otherwise, le level of education about healthy behaviors was suitable in team sport participants than the non-participants.
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