This Study examined ethnicity, cultural and political leadership with Regards to instability in the Republic of Guinea Conakry. The study review literatures and provides strong evidence why Guinea still remains being a dictatorship and authoritarian state. The extant literature revealed the radicalism of the Ethnic Majority In opposition which often cause conflict. Thus, weak opposition and corrupt government wreck the process of development of Republic of Guinea Conakry. The Study concludes that International communities have to support democratic process that will guarantee leadership selection process in the election, this could be a viable stability among ethnic groups.