Volume 18, Issue 2, October 2016, Pages 602–606
S. Jasmin Sugantha Malar1 and T.F. Abbs Fen Reji2
1 Department of Chemistry, Women’s Christian College, Nagercoil, Tamilnadu, India
2 Department of Chemistry and Research Centre, Nesamony Memorial Christian College, Marthandam, Tamilnadu, India
Original language: English
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
In the present investigation, azo compounds were synthesized in good yields via the diazotization of different aromatic amines followed by coupling with indole. The synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR and mass spectral techniques and have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties using disk diffusion method and the minimum inhibitory concentrations (MIC) by the broth micro dilution technique. Their anticancer activity against human breast cancer cell line (MCF7) was determined by MTT assay. All exhibit comparable biological activity.
Author Keywords: Benzo pyrrole, Antimicrobial, Anticancer, Disc diffusion, Broth dilution.
S. Jasmin Sugantha Malar1 and T.F. Abbs Fen Reji2
1 Department of Chemistry, Women’s Christian College, Nagercoil, Tamilnadu, India
2 Department of Chemistry and Research Centre, Nesamony Memorial Christian College, Marthandam, Tamilnadu, India
Original language: English
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
In the present investigation, azo compounds were synthesized in good yields via the diazotization of different aromatic amines followed by coupling with indole. The synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR and mass spectral techniques and have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties using disk diffusion method and the minimum inhibitory concentrations (MIC) by the broth micro dilution technique. Their anticancer activity against human breast cancer cell line (MCF7) was determined by MTT assay. All exhibit comparable biological activity.
Author Keywords: Benzo pyrrole, Antimicrobial, Anticancer, Disc diffusion, Broth dilution.
How to Cite this Article
S. Jasmin Sugantha Malar and T.F. Abbs Fen Reji, “Biological studies of syntheised azo compounds of indole: A comparative study,” International Journal of Innovation and Applied Studies, vol. 18, no. 2, pp. 602–606, October 2016.
