The current study offers some avenues for reflection on an innovative pedagogical approach underpinning the use of information and communication technologies in education (ICT). This research concerns a flipped classroom experience on secondary school students, studying the subject of Family Education, more particularly the sequence of protecting the adolescent against social evils: smoking. In order to operationalize it, we implemented a pedagogical engineering in the light of the ADDIE model (Analysis, Design, Development, Implementation, Evaluation). The study aims at examining the learners' perception of the flipped classroom, in terms of the learner motivation, the quality of teaching-learning, the use of ICT and possible difficulties related to its application. To have a broad understanding of students' views, the study adopted a mixed approach combining quantitative and qualitative methods. The results obtained show, in general, the positive effect of the flipped classroom on students' perception. It responds to their learning paces and increases the teacher-students and students-students interaction, which makes it possible for the learners to perform tasks of a high cognitive level, such as the creation of leaflets and posters to raise awareness of the use of tobacco. The study also reveals the important role that ICTs play in the implementation of the flipped classroom. At the same time, a number of areas for improvement were proposed by the learners concerning the nature of classroom activities, equipment and the online course.