The reduction of the losses post-harvest can contribute to the attack of the food self-sufficiency and the backing of the food security in Burkina. It is in this perspective that this survey has been undertaken and consisted to the assessment of the losses post-harvest of the pennisetum and sorghum in the townships of Ziniaré in the region of the Central Tray and Komki-Ipala in the region of the Center. This assessment carried at home on the links harvest, drying, transportation of the fields and beating / vannage. Iit had for objective to determine the level of the losses. The rate of the quantitative losses is determined according to the methodology of the FAO. The analysis of the sorghum losses revealed 6,33 % to the harvest, 8,63 % to beating / vannage, 2,2 % to the drying and 0,3 % to the transportation at home, for the two townships. So the losses accumulated of sorghum have been estimated to 17,46 %. The losses post-harvest of the pennisetum recorded to the harvest is estimated on average to 6,76 % and 12,53 % to the operations of bombardment / vannage. The heap of the losses of the pennisetum bound to the operations of harvest and bombardment / vannage has been valued to 19,3 %. These results show that the losses post-harvest stays important. The losses of financial incomes by agricultural household are estimated in 55 875 FCFA for sorghum and 42 000 FCFA for the pennisetum. By extrapolation, the quantitative losses of the two cereals considered value themselves to 30 784 tons about for the two regions with an economic value closely 4,336 FCFA billions.