Adansonia digitata L. (baobab) is a multipurpose species in Africa, found in several phytogeographic zones in Côte d'Ivoire. The objective of this study is to contribute to a better knowledge of the morphological and biochemical diversity of the species, according to its distribution area. The study focused on the characterization of morphological descriptors of the fruit and biochemical parameters of 100 baobab fruits from four agroclimatic zones distributed throughout its range. The results obtained revealed a significant difference between the agroclimatic zones for the majority of morphological and biochemical descriptors. At the morphological level, the Niakara zone recorded, in general, the highest average values for the following descriptors: volume (4675.98 ± 2160.51 cm3); whole fruit mass (776.80 ± 286.25 g); pulp mass (222.28 ± 88.62 g) and seed mass (185.00 ± 80.12 g). The biochemical data indicated good overall levels for the parameters studied. The Niakara zone recorded high values for dry matter (88.89 ± 0.13%) and fiber (9.98 ± 0.06%). For total polyphenols, vitamin C and magnesium, the Tiébissou area recorded the highest average values. The high calcium content of the fruits (454.80 ± 3.42 mg/100g) is observed in Kouto. In the whole of the results obtained for the study, it is noted a true morphological and biochemical diversity which could be profitable for the consumers and the breeders.