Matters relating to the negotiation require a clear and rigorous procedure. As such, any political negotiation is spared and every candidate in the negotiation party should have an effective mechanism in response to the different offers that are made. As part of this work, the goal of ours is to assess the negotiating mandate, structures, capacities and response mechanisms for Cameroon's participation in the negotiations of Economic Partnership Agreements (EPAs) with the European Union (EU). To achieve this, we have taken advantage of any existing documentation from which we were able to show the negotiation process follows its normal course. However, the differentiating character of the parties' negotiations blocks developed to date, the ratification of the EPA is not always done. This blockage is partly due to the incompatibility of provisions that confer this agreement with Cameroon commitments in the latter part of sub-regional integration. At this stage, a comprehensive EPA would be the best solution in order to limit the negative effects of this agreement on the survival of regional integration in Central Africa.