The population of the canton of Sédomé, a locality bordering the Togodo-Sud National Park (PNTS) (District of Yoto in Togo), uses a diversity of plant species for which little scientific work has been done. This study is devoted to the inventory of plants and plant recipes with therapeutic potential in Sédomé, with the aim of enhancing the value of these plants. From March to September 2020, an ethnobotanical survey, based on a semi-structured questionnaire, was carried out with 72 practitioners of traditional medicine. 141 species belonging to 60 families have been identified. The most represented families were Fabaceae (12 species), Euphorbiaceae (09 species), Asteraceae and Poaceae (08 species each). The most cited species were: Citrus aurantifolia (Christm. & Panzer) Swingle (7.23%), Newbouldia laevis Seem, (4.22%) and Momordica charantia L. (3.61%). 290 recipes have been inventoried and are used in the treatment of 92 diseases. The decoction (35.86%) and the powder (23.68%) are the main methods of preparation of the recipes which are administered mainly by the oral route (65.34%) and by the cutaneous route (23.93%). The leaves (54.04%) and roots (16.47%) are the most used organs. Most of the organs are collected in riparian vegetation at the PNTS (29.73%), in the gardens (23%) and in the PNTS (20.58%). This study provides a database on plants with therapeutic potential in Sédomé. Future pharmacological studies are possible on these recipes.