This study was carried out to evaluate the acute and subacute toxicity of aqueous extracts of Rhynchospora corymbosa (DRC) and Olax subscorpioidea (DOSA) in Wistar rats. For the study of acute toxicity, the rats divided into 3 batches of 6 subjects (3 males and 3 females) and the aqueous extracts DRC and DOSA were administered once, orally at 2000 mg/kg/bw respectively. for batches 2 and 3. The rats were monitored for 14 days. In the subacute toxicity study, DRC and DOSA aqueous extracts were administered orally to rats at doses 400, 800 and 1600 mg/kg/bw daily for 28 days. Their body weight was monitored during the experimental period, while the hematological and biochemical parameters of the blood and the histo-pathological study of the kidney and liver were evaluated at the end of the experiment. Oral administration of DRC and DOSA aqueous extracts at doses of 2000 mg/kg bw did not result in the death of rats in all treated batches. The subacute toxicity study in rats did not show any toxicity of Rhynchospora corymbosa and Olax subscorpioidea extracts at the doses administered. It appears from all of these results that the aqueous extracts of DRC and DOSA at doses 400; 800 and 1600 mg/kg/bw administered orally to rats is well tolerated and its activity does not cause any harm to the organs, biochemical and hematological parameters as well as to the mass of the animals compared to those of normal rats. The study of the toxicity of DRC and DOSA aqueous extracts did not show signs of acute or subacute toxicity at the doses studied.