The 21st century has been seen as the time of citizen-centered care, with efforts by the World Health Organization (WHO) going towards ensuring that health systems reverse the excessive and exclusively biometric orientation of recent decades. This reorganization of the paradigm requires that patient-centered care be a key dimension of quality in health, creating contexts that value cooperation between citizens and systems. In this relationship, the patient can no longer be seen as inactive, but rather as an element that can influence the entire process linked to medical care. In this paper, we explore the relevance of citizen engagement from a broad and integrative perspective. We begin this reflection with a discussion on the assumptions of Shared Decision-Making in Health that are being implemented in Portugal. Given its relevance, we expand this analysis to justify how citizen involvement is also highly relevant for the development of new information technologies. In this last point, we very briefly present PLAY-THE-ODDS, a project to co-create a communication tool between parents and children about hereditary cancer syndromes.