Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
Vitamin D receptor (VDR) gene is recognized as candidate gene for susceptibility to Type 2 diabetes mellitus (T2DM). The goal of this study was to search the eventual association between VDR gene polymorphisms and T2DM in Moroccans patients. Materials and Methods: 176 patients with T2DM and 177 Healthy controls from the Moroccans population were recruited. Bsm-I(rs1544410), Fok-I(rs10735810) and Apa-I(rs7975232) SNPs of the VDR gene were determined PCR-RFLP. A Vitamin D level was determined using ELISA. Results: The prevalence of Vitamin D inadequancy is higher significantly in patients with T2DM than in the controls subjects. There was a strong association between fok-I polymorphisms with T2DM (OR = 0,35, 95% CI = 0.14
Vitamin D receptor (VDR) gene is recognized as candidate gene for susceptibility to several disease such cardiovascular disease, or arterial hypertension (AHT). The main objective of this study was to investigate a possible association between polymorphisms of the VDR gene and AHT among Moroccan patients. Materials and Methods: 177 clinically diagnosed AHT patients and 222 healthy controls from the Moroccans population were recruited. Bsm-I(rs1544410), Fok-I(rs10735810) and Apa-I (rs7975232) single nucleotide polymorphisms(SNPS) of VDR gene were analyzed using PCR-RFLP reaction. A Vitamin D level was determined using ELISA. Results: Fok-I polymorphism had a strong association with AHT in all genetics models. It was found that FF carriers tend to have higher HDL-c levels than the ff genotypes (55.30
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