The objective of this study is to evaluate the spatial and temporal impact of carbon monoxide-based poisoning on the Moroccan population. This will be fulfilled through the study of the evolution of the impact as morbidity indicator. This assessment will determine the regional populations at risk to better focus the strategic efforts of awareness carried by Poison Control Center and Pharmacovigilance and all health stakeholders in Morocco. Methods: adoption of analytical and cartographic study of the effects of poisoning caused by carbon monoxide, listed by the CAPM, on the populations of Morocco's 16 regions over a period from 1999 to 2013. Results: The trend over time shows a continuous growth of the impact at the national level from 0.025 in 1999 to 0.074 per 1000 inhabitants in 2013. The study of the evolution of regional impacts shows that the people of the Meknes-Tafilalt region are the most exposed to risks of carbon monoxide poisoning in Morocco with an average incidence of 0.112 per 1000 inhabitants. Next come the regions of Tadla-Azilal, Fes-Boulmane, Tanger-Tetouan and the Oriental with an average impact ranging from 0.075 to 0.087 per 1000 inhabitants. Conclusion: The study shows that carbon monoxide poisoning in Morocco is modulated by the weather. Indeed, the highest incidences are recorded in regions with cold temperatures. However, we should not overlook the accidental nature of poisoning linked to the behavior of people in their careless use of heating systems.