Until now, malaria remains a major public health problem in the intertropical zone. The situation is aggravated by the developing resistance of Plasmodium falciparum strains against currently used drugs even artemisinin. Antimalarial new drugs are urgently needed. In this study, we have compared the antiplasmodial activity of defatted ethanolic extracts of four medicinal plants from the traditional pharmacopoeia of Niger to the one of Artemisia annua. We used the Mark III Test of World Health Organization, over the W2 chloroquine-resistant strain of the parasite. Antiplasmodial activity was discussed over the light of phytochemical profile of the plants, determined by standard methods of chemical screening. Cassia nigricans, Sebastiania chamaelea and Euphorbia hirta exhibited good antiplasmodial activity, with respectively IC50 of 2,8
Show abstract
Full Text
