Systemic Lupus Erythematosus (SLE) patients may have arthritis in early stages of the disease. This study aims to investigate the prevalence of anti-CCP in SLE patients from Morocco and its association with HLA class II alleles. Anti-cyclic citrullinated peptide antibodies (Anti-CCP) were measured using ELISA in 88 SLE patients with and without arthritis. Levels ≥ 25 units/ ml defined a positive test of anti-CCP antibodies. Positive anti-CCP was detected in 8 % of SLE patients whose 85.71% % with arthritis and 14.28% without arthritis. The mean titer of anti-CCP antibodies in the SLE group was 83.75 U/ml. HLA class II alleles typing was performed by polymerase chain reaction-sequence-specific primers (PCR-SSP). We found an increase of HLA-DRB1*04 frequency and decrease of DRB1*07 frequency in SLE patients with anti-CCP positive. In the Moroccan population we demonstrated the presence of high titer of anti-CCP in SLE. Results from our study also identified the frequency of HLA-DRB1*04 allele is increased in SLE with anti-CCP positive.
In this work, we tried to find the clinical and therapeutic features and diagnostic difficulties of amyloidosis in pulmonary tuberculosis. For early diagnosis and timely assessment. To evaluate, in a prospective study, adult patients of pulmonary tuberculosis attending our service with subsequent diagnosis of renal amyloidosis AA constituted study population. Clinical profile of biopsy proven amyloidosis cases was analyzed. There were 13 patients (10 males, 3 females, age range 21
All diseases associated with chronic inflammation, whatever the cause (infection, tumor or inflammatory) may be complicated by amyloidosis. The occurrence of amyloidosis in the development of lupus disease is exceptional. Are there such conditions for this association? We report two cases involving lupus and amyloidosis followed in the Department of Internal Medicine of CHU Ibn Sina Rabat.
Show abstract
Full Text
