Introduction: Acne is a common disease. His impact on quality of life (QOL) had not yet been studied in Burkina. Our objective was to describe the degree of impaired QOL in students with acne in Ouagadougou and then determine the correlation between the severity of acne and their QOL. Methods: We conducted a cross-sectional study in two examination centers of Ouagadougou and included, with their consent, students candidates to BEPC and BAC exams of selected juries. The grid ECLA was used for clinical evaluation of acne, CADI grid for QOL. Results: We recruited 311 students with 59.4% of boys and 40.60% girls. The average age was 19.5 years with extremes of 13 and 28 years. The prevalence of acne was 56.27% (175/311). Acne was considered mild to moderate in 95.43% (167/175) and severe in 4.75% (8/175). The global severity score ECLA averaged 5.84 ± 3.62 with extremes of between 0 and 21. There was an alteration of QOL among all acne pupils. This alteration was important for 36.78% of the subjects, average for 37.51% and mild for 25.71%. The total score of the CADI was 1.736 ± 0.892 on 15. A positive correlation between the severity of acne and impaired QOL was observed. A positive link was found between the severity of acne and the degree of impairment of social relationships. A positive link was also found between the severity of acne and the sinking feeling inspired by his skin to the student acne.