Haemophilus influenzae, holds a dominating role in the low respiratory infections. These infections constitute a real problem of public health especially because of the appearance these last years of resistant strains questioning the classic antibiotic treatment. This resistance mainly concerns betalactamins, in particular aminopenicillins. A retrospective study was made over a period of 5 years (September 2011-, 2016) with the aim of establishing the epidemiological profile of the low respiratory infections to H. influenzae, determining the resistance to antibiotics of this germ to guide better the therapeutic and preventive strategies. The identification was based on the requirements in factors X and V and the production of betalactamases was looked for by means of the cefinase. During the period of study, 123 tree strains were isolated among which 73 % resulted from intensive care units and from pneumology. The production of betalactamases for all the isolated tree strains was 31 %. Resistant strains in the amoxicillin by production of betalactamase were sensitive to the association clavulanic amoxicillin-acid in 28 % of the cases. The resistance in the other antibiotics was 16 % in the trimethoprim sulfamethoxazole, 4.8 % in fluoroquinolones and 2.5 % in tetracyclines. No resistance in cephalosporins 3rd generation was observed.