This article analyzes the relationship between entrepreneurship and economic growth for a panel of developed and developing countries during the period 1990-2004, as well as the importance of the social capital in the relationship between entrepreneurship and economic growth. Our study will be conducted using the method of static data panel. The main results of this study are, first, the level of social capital and entrepreneurship are significantly and positively correlated, on the other hand, a high level of social capital as an indirect effect on economic growth through its effect on the entrepreneurial activity. Thus, this article aims to develop elements of theoretical and empirical answers to the effect of a sound institutional environment and adequate capital on enhancing entrepreneurial activity that would have positive effects on investment and economic growth.