Introduction: Uterine prolapse is a descent of the uterus into the small pelvis that can be associated with the descent of the vagina, the bladder and the rectum. In this study, our goal was to determine the prevalence and major risk factors for uterine prolapse in Kisangani, and to describe its management. Material and methods: A cross-sectional study with a descriptive and multicentric focus was carried out in 5 main general reference hospitals and university clinics in the town of Kisangani from 1st January 2005 to 1st January 2015. We selected 43 cases of uterine prolapse on 7039 cases of gynecological pathologies. Results: The prevalence of uterine prolapse is 0.61% in Kisangani; 93.02% had consulted for organ removal and 69.76% for abdomino-pelvic pain. 20.93% of these patients were aged 61-70 years, 18.6% were over 70 years of age with Extremes: 18 and 73 years, 76.73% had a parity greater than or equal to 4, 12.05% were obese and 32.53% of patients were HIV positive. The Dolleris-Pellonda was performed in 51.16% and the total hysterectomy at 34.88%. Recurrences were recorded in 16.27% of cases. Conclusion: Uterine prolapse remains a reality in medical practice in our town. If several risk factors are found, it is also appropriate to retain the role played by HIV / AIDS infection in the genesis of this disease.