[ L'allo-immunisation érythrocytaire fœto-maternelle : Revue de la littérature ]
Volume 14, Issue 1, January 2016, Pages 68–72
Ibrahim Abdellahi1, Osman Ali2, Farid Kassidi3, Abdellah Babahabib4, Jaouad Kouach5, Driss Moussaoui6, and Mohammed Dehayni7
1 Hôpital Militaire d'Instruction de Mohamed V, Rabat, Morocco
2 Hôpital Militaire d'Instruction de Mohamed V, Rabat, Morocco
3 Department of Gynecology-Obstetric, Military Training Hospital Med V, Rabat, Morocco
4 Department of obstetrics & gynecology, Military Training Hospital Mohamed V, Rabat, Morocco
5 Faculté de Médecine et de Pharmacie, Université Mohamed V, Rabat, Morocco
6 Department of Gynecology-Obstetric, Military Training Hospital Med V, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
7 Department of Gynecology-Obstetric, Military Training Hospital Med V, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
Original language: French
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Feto-maternal red cell alloimmunization is defined by the presence in a pregnant woman of alloantibodies directed against blood group antigens present on the red blood cells of the fetus and inherited by the father. It arises from the immune response to a first contact to these same antigens during a prior transfusion, transplant or pregnancy. The placental transfer and the fixation of the antibodies on the fetal red cells antigenic targets lead to a haemolysis in the fetus and the newborn. The resulting haemolytic disease can show different clinical forms, from a mild anaemia with neonatal hyperbilirubinemia to a major fetal damage with stillbirth caused by hydrops fetalis. The objective of management strategies of feto-maternal alloimmunization is to detect and monitor maternal alloimmunization and to appreciate the effects on the fetus or the newborn.
Author Keywords: Red cell feto-maternal alloimmunization, Haemolytic disease of the fetus and newborn, Biological surveillance of pregnancy, Neonatal transfusion, Intrauterine transfusion, RH1 immunization prophylaxis.
Volume 14, Issue 1, January 2016, Pages 68–72
Ibrahim Abdellahi1, Osman Ali2, Farid Kassidi3, Abdellah Babahabib4, Jaouad Kouach5, Driss Moussaoui6, and Mohammed Dehayni7
1 Hôpital Militaire d'Instruction de Mohamed V, Rabat, Morocco
2 Hôpital Militaire d'Instruction de Mohamed V, Rabat, Morocco
3 Department of Gynecology-Obstetric, Military Training Hospital Med V, Rabat, Morocco
4 Department of obstetrics & gynecology, Military Training Hospital Mohamed V, Rabat, Morocco
5 Faculté de Médecine et de Pharmacie, Université Mohamed V, Rabat, Morocco
6 Department of Gynecology-Obstetric, Military Training Hospital Med V, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
7 Department of Gynecology-Obstetric, Military Training Hospital Med V, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
Original language: French
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Feto-maternal red cell alloimmunization is defined by the presence in a pregnant woman of alloantibodies directed against blood group antigens present on the red blood cells of the fetus and inherited by the father. It arises from the immune response to a first contact to these same antigens during a prior transfusion, transplant or pregnancy. The placental transfer and the fixation of the antibodies on the fetal red cells antigenic targets lead to a haemolysis in the fetus and the newborn. The resulting haemolytic disease can show different clinical forms, from a mild anaemia with neonatal hyperbilirubinemia to a major fetal damage with stillbirth caused by hydrops fetalis. The objective of management strategies of feto-maternal alloimmunization is to detect and monitor maternal alloimmunization and to appreciate the effects on the fetus or the newborn.
Author Keywords: Red cell feto-maternal alloimmunization, Haemolytic disease of the fetus and newborn, Biological surveillance of pregnancy, Neonatal transfusion, Intrauterine transfusion, RH1 immunization prophylaxis.
Abstract: (french)
L'allo-immunisation érythrocytaire fœto-maternelle est définie par la présence chez une femme enceinte d'alloanticorps dirigés contre des antigènes de groupe sanguin présents sur les hématies du fœtus et hérités du père. Elle résulte de la réponse immunitaire à un contact préalable avec ces mêmes antigènes lors de transfusion, greffe ou lors d'une grossesse antérieure. Le transfert placentaire et la fixation des anticorps sur les cibles antigéniques érythrocytaires fœtales provoquent une hémolyse chez le fœtus et le nouveau-né. La maladie hémolytique qui en résulte peut présenter des formes cliniques variées allant d'une anémie avec hyperbilirubinémie néonatale modérées jusqu'à une atteinte fœtale majeure avec mort in utero par anasarque foetoplacentaire. La prise en charge des allo-immunisations fœto-maternelles a pour objectif de dépister et de surveiller l'allo-immunisation maternelle et d'en apprécier le retentissement fœtal ou néonatal afin de mettre en place le traitement le plus adapté.
Author Keywords: Allo-immunisation fœto-maternelle érythrocytaire, Maladie hémolytique du fœtus et du nouveau-né, Surveillance biologique de la grossesse, Transfusion néonatale, transfusion in utero, Prévention de l'allo-immunisation anti-RH1.
How to Cite this Article
Ibrahim Abdellahi, Osman Ali, Farid Kassidi, Abdellah Babahabib, Jaouad Kouach, Driss Moussaoui, and Mohammed Dehayni, “Foetomaternal red blood cell alloimmunization : literature review,” International Journal of Innovation and Applied Studies, vol. 14, no. 1, pp. 68–72, January 2016.
