International Journal of Innovation and Applied Studies
ISSN: 2028-9324     CODEN: IJIABO     OCLC Number: 828807274     ZDB-ID: 2703985-7
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Severe Cutaneous adverse reactions Caused by Black Henna in Morocco - Series cases report

Volume 17, Issue 2, July 2016, Pages 460–463

 Severe Cutaneous adverse reactions Caused by Black Henna in Morocco - Series cases report

Houda Sefiani1, Ghita Benabdallah2, Houda OUBEJJA3, Abdelmajid Soulaymani4, and Rachida Soulaymani-Bencheikh5

1 Centre Antipoison et de pharmacovigilance du Maroc à Rabat (CAPM), Morocco
2 Centre Anti Poison et de Pharmacovigilance du Maroc (CAPM), Rabat, Morocco
3 Service des Urgences Chirurgicales Pédiatriques, Hôpital d’Enfants de Rabat, Morocco
4 Laboratory of Genetics and Biometry, Faculty of Sciences of Kenitra, University Ibn Tofail, Kenitra, Morocco
5 Faculté de Médecine et de Pharmacie, Université Mohammed V - Souissi, Rabat, Morocco

Original language: English

Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Traditional henna rarely causes adverse events. However, to obtain a black color, many ingredients are mixed with this plant such as paraphenylene diamine and solvents. The aim of our study is to describe severe cutaneous adverse events caused by black henna collected at the Moroccan Pharmacovigilance Centre. Materials and Methods: We analyzed the coetaneous adverse reactions associated with the use of black henna, collected during 2012 in Morocco. The severity ofreactions wasan inclusion criteria. We analyzed the characteristics of patients, adverse reactions and type of exposure. Results: Nine serious cutaneous cases were collected, which represent 6.42% of all adverse reactions related to cosmetics products. Hospitalization and sequelae were the reason of seriousness. Outcomes were favorable for all cases. Conclusion: the severity of those cases showed the importance of the pharmacovigilance of cosmetics products.

Author Keywords: black henna, pharmacovigilance, cutaneous adverse reaction.

How to Cite this Article

Houda Sefiani, Ghita Benabdallah, Houda OUBEJJA, Abdelmajid Soulaymani, and Rachida Soulaymani-Bencheikh, “Severe Cutaneous adverse reactions Caused by Black Henna in Morocco - Series cases report,” International Journal of Innovation and Applied Studies, vol. 17, no. 2, pp. 460–463, July 2016.