Adenoid cystic carcinoma of Bartholin’s gland is a rare tumor. Its management is inspired by the treatment of vulvar cancers. We present here a clinical case of a 28-year-old female patient who presented with a painful swelling of the left labia majora, which was mistaken for simple bartholinitis and treated medically without improvement. A biopsy was then performed, and the histopathological study revealed a cystic adenoid carcinoma of the Bartholin gland. The radiological workup showed a locally advanced left vulvar process, without distant metastasis. Due to the impossibility of surgery, concomitant radiotherapy and chemotherapy were performed, with good improvement. The rarity of this type of vascular cancer makes its diagnosis late, because it is often confused with bartholin gland cyst and bartholinitis. Moreover, its management is still not standardized.

Colloid carcinoma of the breast is a rare histological entity, representing only 1 to 6% of all breast carcinomas. It affects a specific population and is known for its favorable prognosis compared to other breast cancers. Through three clinical cases of colloid carcinoma and a review of the literature, we will try to discuss the main clinical-pathological and evolutionary characteristics of this rare form of breast cancer.

Malignant melanoma of the female genital tract is rare, and its localization in the cervix is exceptional, it represents 3% of malignant melanomas of the female genital tract, At the initial stage of malignant melanoma of the cervix, the disease is limited to the cervical mucosa, subsequently it spreads locally via direct diffusion to adjacent organs, Clinically there are asymptomatic cases diagnosed during a routine examination, However, more often one has the presence of symptoms, because the cervix ulceration expands easily and become infected. The most common symptom is vaginal bleeding. Macroscopically, primary malignant melanoma presents variable appearances, The spectrum of cellular characteristics is broad, Immunohistochemical markers may be positive in primary cervical malignant melanoma such as S-100, HMB-45, Melan-A, Vimentin, and SOX10, Differential Diagnosis of Primary Malignant Melanoma of the Cervix requires the exclusion of metastatic malignant melanoma, or other primary neoplastic site, mainly dermal, Once the diagnosis of malignant melanoma of the cervix is confirmed, the full staging of the disease should be establishment. This is based on performing a tomography (whole-body CT) or a positron emission tomography (PET / CT), the determination of serum lactate dehydrogenase.The therapeutic approach is not standardized but is rather individualized according to the characteristics of the disease and the patient.