16 dogs (Canis familiaris) of local breed 12 males for castration, 4 females for the diagnosis of an unknown pathology were administered a combination of anesthetic agents which included medium drugs of Xylazine 1.49 mg / kg) for premedication. After 10 minutes the animal was injected with an average dose of ketamine 14.72 (mg / kg). The infusion route and the parameters were recorded every 10 minutes time intervals (heart rate, respiratory rates, oxygen saturation, temperature, color of the mucous membrane, reflexes, capillary replenishment, blood sugar level and carbon dioxide). At 29.9 minutes, the injection of Diazepam came through the vein to sedate the animal. The average heart rate of the individuals was 86.89 beats per minute that of all intervals was 88.06 beats per minute. Respiratory rate was 16.73 breaths per minute and the average of all intervals was 21.89 breaths per minute. The average temperature for all individuals was 37.13 0C and for all intervals were 36.90C. The average oxygen saturation for individuals was 91.57% that for all intervals was 91.96%. The carbon dioxide for individuals was 32.52 mmHg and for all intervals was 31.4 mmHg. Anesthesia in dogs for suppression of the pain, good muscle relaxation and anesthetic depth that can ensure the well-being of animals and the surgical procedure.