This study reviews the current state of knowledge on the roles of lysine and methionine in monogastric nutrition, and their potential availability in feedstuffs for pigs and chickens in Burkina Faso. It aims to better orient ongoing research to make these amino acids more available and optimize their content in local feed resources and their use in the rationing of pigs and chickens on intensive farms in Burkina Faso. Searches carried out mainly online using the Google Scholar search engine yielded a wide range of documents, which were filtered to retain only the most significant ones dealing with the above-mentioned themes. A total of 294 documents were identified, from which 126 references were selected and used for this literature review. Lysine and methionine are the most limiting amino acids in pig and chicken feed, in that their deficiency in rations affects feed efficiency, leads to reduced growth and dysfunctions in the organism. The methionine and lysine used in Burkina Faso are imported synthetic products that are not easily accessible due to their high cost. Their availability in certain ingredients can be improved by germination and/or heat treatment. Compliance with recommended lysine and methionine requirements in formulations for pigs and chickens is essential to optimize their utilization by the body, while reducing nitrogen losses and ensuring good productivity.