With the aim of contributing to the protection of corn against the larvae of Spodoptera frugiperda JE Smith in Burkina Faso, we evaluated the effectiveness of four phytosanitary treatments based on chemical insecticides for the protection of corn plants. The experimental setup is a Fisher block comprising 04 repetitions and 7 treatments. Our study showed a significant effect of the number of insecticide treatments on the infestation rate, larval density but also the severity of damage caused to plants. However, the number of insecticide treatments evaluated in this study did not have a significant effect on yield (Pr( F = 0.531). The average yield of the plants was statistically identical when the plants were protected seven, three and two times with synthetic insecticides based on Emamectin benzoate and Flubendiamide + Thiacloprid. Furthermore, the yield analysis also does not show any difference between untreated plots and plots having received synthetic insecticide applications. It appears from this study that high numbers of insecticide treatments do not necessarily lead to an increase in yield. In areas heavily affected by the pest, three insecticide applications based on approved synthetic insecticides can be used against S. frugiperda damage.